Mefloquine Treatment in a Patient Suffering from Progressive Multifocal Leukoencephalopathy after Umbilical Cord Blood Transplant

被引：32

作者：

Kishida, Shuji ^{[1
]}

Tanaka, Kozue ^{[1
]}

机构：

[1] Komagome Hosp, Tokyo Metropolitan Canc & Infect Dis Ctr, Div Neurol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 22期

关键词：

progressive multifocal leukoencephalopathy; mefloquine;

D O I：

10.2169/internalmedicine.49.3227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report herein the case of a 37-year-old man who developed probable progressive multifocal leukoencephalopathy (PML) following an umbilical cord blood transplant. The patient showed favorable clinical, neuroradiological and virological responses after treatment with mefloquine, an anti-malarial drug. Mefloquine may offer some benefits as a treatment for PML in patients with or without human immunodeficiency virus type-1 infection. This report highlights the need to gather sufficient data to confirm the efficacy of mefloquine against this devastating viral disease of the central nervous system.

引用

页码：2509 / 2513

页数：5

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