Effects of adrenalectomy on CART expression in the rat arcuate nucleus

被引：35
作者：
Balkan, B
Koylu, E
Pogun, S
Kuhar, MJ
机构：
[1] Emory Univ, Yerkes Natl Primate Res Ctr, Div Neurosci, Atlanta, GA 30329 USA
[2] Ege Univ, Ctr Brain Res, Sch Med, Dept Physiol, Izmir, Turkey
来源：
SYNAPSE | 2003年 / 50卷 / 01期
关键词：
CART peptide; adrenalectomy; arcuate nucleus; leptin; stress;
D O I：
10.1002/syn.10213
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In order to test for glucocorticoid regulation of CART in the arcuate nucleus, adrenalectomies (ADX) and hormone replacements (HRs) were carried out in groups of rats. CART mRNA levels were determined by in situ hybridization and CART peptide levels by immunocytochemistry. ADX caused a lowering of CART mRNA and peptides levels in the arcuate and this was reversed by HR. These results indicate a glucocorticoid regulation of CART in the arcuate. The regulation could be direct through an action of glucocorticoid receptors or indirectly through ADX-induced changes in leptin levels. These findings suggest a role for CART in the stress response. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：14 / 19
页数：6
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