SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists

被引：33

作者：

Chu, L

Lo, JL

Yang, YT

Cheng, K

Smith, RG

Fisher, MH

Wyvratt, MJ

Goulet, MT

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Biochem & Physiol, Rahway, NJ 07065 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00708-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery of the potency-enhancing effect of 5-substitutions on the novel 2-arylindoles as nonpeptidyl GnRH receptor antagonists led to the identification of several analogues with high affinities on the GnRH receptor. The syntheses and SARs of these 5-substituted-2-arylindole analogues are reported. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：515 / 517

页数：3

共 5 条

[1] Discovery of a novel, potent, and orally active nonpeptide antagonist of the human luteinizing hormone-releasing hormone (LHRH) receptor [J].