Epigenetic mechanisms in Parkinson's disease

被引：88

作者：

Feng, Ya ^{[1
]}

Jankovic, Joseph ^{[2
,3
]}

Wu, Yun-Cheng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Neurol, Shanghai 200080, Peoples R China

[2] Baylor Coll Med, Dept Neurol, Parkinsons Dis Ctr, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Neurol, Movement Disorders Clin, Houston, TX 77030 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2015年 / 349卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; Epigenetic modification; DNA methylation; Histone acetylation; Non-coding RNAs; ALPHA-SYNUCLEIN EXPRESSION; DNA METHYLATION; DOPAMINERGIC-NEURONS; ENVIRONMENTAL-FACTORS; HISTONE ACETYLATION; OXIDATIVE STRESS; MOUSE MODEL; BRAIN; HOMOCYSTEINE; ASSOCIATION;

D O I：

10.1016/j.jns.2014.12.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is the second most common age-related neurodegenerative disease, but its pathogenesis is not fully understood. The selective neuronal cell death in PD has been considered to result from a complex interaction between genetic and environmental factors, but the nature of the relationship between the two chief modifiers remains to be elucidated. There is a growing body of evidence supporting the role of epigenetics in the development and progression of many neurodegenerative diseases including PD. Epigenetic modification refers to changes in gene expression or function without changes in DNA sequence, which mainly includes DNA methylation, post-modifications of histone, and non-coding RNAs. In this review, we will focus on the abnormal epigenetic modifications involved in the pathogenesis of PD and their implications for the development of future diagnostic and therapeutic strategies. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：3 / 9

页数：7

共 77 条

[31] Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1 [J].