Vitamin D and the development of allergic disease: how important is it?

被引：109

作者：

Mirzakhani, H. ^{[1
,2
]}

Al-Garawi, A. ^{[1
,2
]}

Weiss, S. T. ^{[1
,2
,3
]}

Litonjua, A. A. ^{[1
,2
,4
]}

机构：

[1] Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Partners HealthCare Ctr Personalized Genet Med, Boston, MA USA

[4] Brigham & Womens Hosp, Div Pulm & Crit Care Med, Dept Med, Boston, MA 02115 USA

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 2015年 / 45卷 / 01期

关键词：

REGULATORY T-CELLS; SERUM 25-HYDROXYVITAMIN D; NATURAL-KILLER-CELLS; GENOME-WIDE ASSOCIATION; RAT LUNG EXPLANTS; D DEFICIENCY; ATOPIC-DERMATITIS; D SUPPLEMENTATION; 1,25-DIHYDROXYVITAMIN D-3; D-RECEPTOR;

D O I：

10.1111/cea.12430

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Vitamin D has known effects on lung development and the immune system that may be important in the development, severity, and course of allergic diseases (asthma, eczema, and food allergy). Vitamin D deficiency is prevalent worldwide and may partly explain the increases in asthma and allergic diseases that have occurred over the last 50-60years. In this review, we explore past and current knowledge on the effect of vitamin D on lung development and immunomodulation and present the evidence of its role in allergic conditions. While there is growing observational and experimental evidence for the role of vitamin D, well-designed and well-powered clinical trials are needed to determine whether supplementation of vitamin D should be recommended in these disorders.

引用

页码：114 / 125

页数：12

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