gutMGene: a comprehensive database for target genes of gut microbes and microbial metabolites

被引：117
作者：
Cheng, Liang [1 ,2 ,3 ]
Qi, Changlu [3 ]
Yang, Haixiu [3 ]
Lu, Minke [3 ]
Cai, Yiting [3 ]
Fu, Tongze [3 ]
Ren, Jialiang [3 ]
Jin, Qu [3 ]
Zhang, Xue [1 ,2 ,4 ]
机构：
[1] Harbin Med Univ, NHC, Harbin 150028, Heilongjiang, Peoples R China
[2] Harbin Med Univ, CAMS Key Lab Mol Probe & Targeted Theranost, Harbin 150028, Heilongjiang, Peoples R China
[3] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150081, Heilongjiang, Peoples R China
[4] Peking Union Med Coll, McKusick Zhang Ctr Genet Med, Beijing 100005, Peoples R China
来源：
NUCLEIC ACIDS RESEARCH | 2022年 / 50卷 / D1期
基金：
中国国家自然科学基金;
关键词：
HEALTH; SHAPE;
D O I：
10.1093/nar/gkab786
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
gutMGene (http://bio-annotation.cn/gutmgene), a manually curated database, aims at providing a comprehensive resource of target genes of gut microbes and microbial metabolites in humans and mice. Metagenomic sequencing of fecal samples has identified 3.3 x 10(6) non-redundant microbial genes from up to 1500 different species. One of the contributions of gut microbiota to host biology is the circulating pool of bacterially derived small-molecule metabolites. It has been estimated that 10% of metabolites found in mammalian blood are derived from the gut microbiota, where they can produce systemic effects on the host through activating or inhibiting gene expression. The current version of gutMGene documents 1331 curated relationships between 332 gut microbes, 207 microbial metabolites and 223 genes in humans, and 2349 curated relationships between 209 gut microbes, 149 microbial metabolites and 544 genes in mice. Each entry in the gutMGene contains detailed information on a relationship between gut microbe, microbial metabolite and target gene, a brief description of the relationship, experiment technology and platform, literature reference and so on. gutMGene provides a user-friendly interface to browse and retrieve each entry using gut microbes, disorders and intervention measures. It also offers the option to download all the entries and submit new experimentally validated associations.
引用
收藏
页码：D795 / D800
页数：6
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