Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex

被引：56
|
作者：
Yang, MY [1 ]
Richard, JP [1 ]
Morrow, JR [1 ]
机构：
[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA
来源：
CHEMICAL COMMUNICATIONS | 2003年 / 22期
关键词：
D O I：
10.1039/b308644e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The 2.4 kcal mol(-1) greater stabilization of the transition state for cleavage of the minimal substrate HpPNP compared to the nucleoside substrate UpPNP by the efficient dinuclear metal ion catalyst Zn-2(L2O) provides evidence that access to the cationic core of Zn-2(L2O) is sterically blocked for the bulkier nucleoside substrates, a flaw that will need to be dealt with in later generations of metal ion catalysts of RNA cleavage.
引用
收藏
页码：2832 / 2833
页数：2
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