Fecal microbiota transplantation in a kidney transplant recipient with recurrent urinary tract infection

被引：52

作者：

Biehl, Lena M. ^{[1
,2
]}

Aguilar, Rebeca Cruz ^{[1
,2
]}

Farowski, Fedja ^{[1
]}

Hahn, Werner

Nowag, Angela ^{[3
,4
]}

Wisplinghoff, Hilmar ^{[3
,4
,5
]}

Vehreschild, Maria J. G. T. ^{[1
,2
]}

机构：

[1] Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany

[2] German Ctr Infect Res, Partner Site Bonn Cologne, Cologne, Germany

[3] Wisplinghoff Labs, Cologne, Germany

[4] Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany

[5] Witten Herdecke Univ, Inst Virol & Med Microbiol, Witten, Germany

来源：

INFECTION | 2018年 / 46卷 / 06期

关键词：

Recurrent urinary tract infection; Fecal microbiota transplantation; Urinary microbiome; Non-antibiotic prophylaxis; CLOSTRIDIUM-DIFFICILE INFECTION;

D O I：

10.1007/s15010-018-1190-9

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose We report on a kidney transplant recipient treated with fecal microbiota transplantation (FMT) for recurrent urinary tract infections. Methods FMT was administered via frozen capsulized microbiota. Before and after FMT, urinary, fecal and vaginal microbiota compositions were analyzed. Results The patient remained without symptoms after FMT. Conclusions Underlying mechanisms of action need to be addressed in depth by future research.

引用

页码：871 / 874

页数：4

共 12 条

[1]

[Anonymous], 2016, R LANG ENV STAT COMP

[2]

Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]

[3] Determinants of Antimicrobial Resistance in Escherichia coli Strains Isolated from Faeces and Urine of Women with Recurrent Urinary Tract Infections [J].

den Heijer, Casper D. J. ;

Beerepoot, Marielle A. J. ;

Prins, Jan M. ;

Geerlings, Suzanne E. ;

Stobberingh, Ellen E. .

PLOS ONE, 2012, 7 (11)

[4] Urinary tract infections: epidemiology, mechanisms of infection and treatment options [J].

Flores-Mireles, Ana L. ;

Walker, Jennifer N. ;

Caparon, Michael ;

Hultgren, Scott J. .

NATURE REVIEWS MICROBIOLOGY, 2015, 13 (05) :269-284

[5] Recurrent urinary tract infection in women [J].

Hooton, TM .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 17 (04) :259-268

[6]

Illumina, 2016, 16S SAMPL PREP GUID

[7] Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections [J].

Schreiber, Henry L. ;

Conover, Matt S. ;

Chou, Wen-Chi ;

Hibbing, Michael E. ;

Manson, Abigail L. ;

Dodson, Karen W. ;

Hannan, Thomas J. ;

Roberts, Pacita L. ;

Stapleton, Ann E. ;

Hooton, Thomas M. ;

Livny, Jonathan ;

Earl, Ashlee M. ;

Hultgren, Scott J. .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (382)

[8] Randomized, Placebo-Controlled Phase 2 Trial of a Lactobacillus crispatus Probiotic Given Intravaginally for Prevention of Recurrent Urinary Tract Infection [J].

Stapleton, Ann E. ;

Au-Yeung, Melissa ;

Hooton, Thomas M. ;

Fredricks, David N. ;

Roberts, Pacita L. ;

Czaja, Christopher A. ;

Yarova-Yarovaya, Yuliya ;

Fiedler, Tina ;

Cox, Marsha ;

Stamm, Walter E. .

CLINICAL INFECTIOUS DISEASES, 2011, 52 (10) :1212-1217

[9] Escherichia coli 83972 Bacteriuria Protects Against Recurrent Lower Urinary Tract Infections in Patients With Incomplete Bladder Emptying [J].

Sunden, Fredrik ;

Hakansson, Lars ;

Ljunggren, Eva ;

Wullt, Bjorn .

JOURNAL OF UROLOGY, 2010, 184 (01) :179-185

[10]

TACKE D, 2015, CLIN MICROBIOL INFEC, V21, pE82, DOI DOI 10.1016/j.cmi.2015.06.027

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