Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases

被引：33
作者：
Alkozi, Hanan A. [1 ]
Franco, Rafael [2 ,3 ]
Pintor, Jesus J. [1 ]
机构：
[1] Univ Complutense Madrid, Fac Opt & Optometry, Dept Biochem & Mol Biol 4, Madrid, Spain
[2] Univ Barcelona, Dept Biochem & Mol Biomed, IBUB, Barcelona, Spain
[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Cell & Mol Neuropharmacol, Madrid, Spain
来源：
FRONTIERS IN GENETICS | 2017年 / 8卷
关键词：
cataracts; glaucoma; dry eye; keratoconus; eye diseases; LONG NONCODING RNAS; OPEN-ANGLE GLAUCOMA; ALPHA-CRYSTALLIN; HISTONE DEACETYLASE; WIDE ASSOCIATION; VALPROIC ACID; GENE; TRANSCRIPTION; ACETYLATION; SUPPRESSION;
D O I：
10.3389/fgene.2017.00144
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for nongenetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.
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页数：7
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