Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

被引：22

作者：

Tian, Jinfan ^{[1
]}

Popal, Mohammad Sharif ^{[2
]}

Huang, RongChong ^{[3
]}

Zhang, Min ^{[1
]}

Zhao, Xin ^{[1
]}

Zhang, Mingduo ^{[1
]}

Song, Xiantao ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China

[2] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiac Surg, Beijing 100029, Peoples R China

[3] Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100010, Peoples R China

来源：

AGING AND DISEASE | 2020年 / 11卷 / 02期

关键词：

Caveolin; autophagy; cardiovascular disease; role; target; MEDIATED CHOLESTEROL EFFLUX; NITRIC-OXIDE SYNTHASE; OPERATED CA2+ ENTRY; P42/44 MAP KINASE; PULMONARY-HYPERTENSION; DENSITY-LIPOPROTEIN; SELECTIVE UPTAKE; MICE DEVELOP; OXIDIZED LDL; CELL-DEATH;

D O I：

10.14336/AD.2019.09603

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.

引用

页码：378 / 389

页数：12

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