Update on the genetics of spondyloarthritis - ankylosing spondylitis and psoriatic arthritis

被引：20

作者：

Chandran, Vinod ^{[1
]}

Rahman, Proton ^{[2
]}

机构：

[1] Univ Toronto, Dept Med, Div Rheumatol, Toronto, ON, Canada

[2] Mem Univ Newfoundland, St John, NF, Canada

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2010年 / 24卷 / 05期

关键词：

Psoriasis; Major histocompatibility complex; Human leukocyte antigen genes; Genetic linkage; Genetic association; Endoplasmic reticulum (ER) associated aminopeptidase 1; Interleukin; 23; receptor; Gene deserts; GENOME-WIDE ASSOCIATION; MICA RATHER; TNF-ALPHA; HLA-C; SUSCEPTIBILITY; DISEASE; POLYMORPHISMS; GENES; RISK; COMPLEX;

D O I：

10.1016/j.berh.2010.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Spondyloarthritis refers to a group of inflammatory rheumatic diseases that share common clinical and genetic characteristics Due to the rapid advances in technology and computational genetics there is now an increasing list of well-validated genes in spondyloarthritis The newest genetic associations are of modest magnitude and have been identified as a result of analysing thousands of samples using genome-wide association scans or targeted candidate-gene association studies In this article we will highlight the genes associated with spondyloarthruis with an emphasis on the recent candidate genes that have been identified in ankylosing spondylitis and psoriatic arthritis If applicable we will also discuss their potential relevance to the clinical rheumatologist (C) 2010 Elsevier Ltd All rights reserved

引用

页码：579 / 588

页数：10

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