Liver Glucokinase: An Overview on the Regulatory Mechanisms of its Activity

被引：101
作者：
Massa, Maria L. [1 ]
Gagliardino, Juan J. [1 ]
Francini, Flavio [1 ]
机构：
[1] UNLP CONICET LA PLATA, Fac Ciencias Med, CENEXA, Ctr Colaborador OPSIOMS, RA-1900 La Plata, Argentina
来源：
IUBMB LIFE | 2011年 / 63卷 / 01期
关键词：
glucokinase; glucose homeostasis; liver; liver glucokinase activity; transcriptional and post-transcriptional glucokinase activity regulation; ELEMENT-BINDING PROTEIN-1C; PHOSPHOFRUCTOKINASE-2/FRUCTOSE BISPHOSPHATASE-2; HEPATIC GLUCOKINASE; GLUCOSE-METABOLISM; GENE-EXPRESSION; RECEPTOR-ALPHA; NUCLEAR EXPORT; POTENTIAL ROLE; ENZYME GENE; INSULIN;
D O I：
10.1002/iub.411
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a complex set of mechanisms: in the postprandial period, the simultaneous rise in glucose and insulin increases GCK activity by enhanced gene expression, changes in cellular location, and interaction with regulatory proteins. Conversely, in the fasting state, the combined decrease in glucose and insulin concentrations and increase in glucagon concentrations, halt GCK activity. Herein we summarize the current knowledge regarding the regulation of hepatic GCK activity. (C) 2011 IUBMB IUBMB Life, 63(1): 1-6, 2011
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页码：1 / 6
页数：6
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