Supersymmetric grand unified theories based on the gauge group SO(10) are highly motivated. In the simplest models, one expects t - b - tau Yukawa coupling unification, in addition to gauge, matter and Higgs unification. Yukawa unification only occurs with very special GUT scale boundary conditions, leading to a spectra with similar to 10 TeV first and second generation scalars, TeV-scale third generation scalars, and light gauginos. The relic density of neutralino cold dark matter is calculated to be 10(2) - 10(4) times higher than observation. If we extend the theory with the PQ solution to the strong CP problem, then instead a mixture of axions and axinos comprises the dark matter, with the measured abundance. Such a solution solves several cosmological problems. We predict a rather light gluino with m((g) over bar) similar to 300 - 500 GeV that should be visible in either Tevatron or forthcoming LHC run I data. We would also expect ultimately a positive result from relic axion search experiments.