New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries

被引：35

作者：

Goncalves, G. M.

Castoldi, A. ^{[2
]}

Braga, T. T.

Camara, N. O. S. ^{[1
,2
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci 4, Dept Immunol, Lab Transplantat Immunobiol, BR-05508900 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Escola Paulista Med, Div Nephrol, Lab Clin & Expt Immunol, Sao Paulo, Brazil

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2011年 / 73卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

TOLL-LIKE RECEPTORS; ACUTE-RENAL-FAILURE; PATTERN-RECOGNITION RECEPTORS; NF-KAPPA-B; NEUTROPHIL MIGRATION; NLRP3; INFLAMMASOME; CELL APOPTOSIS; SEVERE SEPSIS; EXPRESSION; ACTIVATION;

D O I：

10.1111/j.1365-3083.2011.02523.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. They can recognize exogenous Pathogen-Associated Molecular Patterns and endogenous Dangers-Associated Molecular Patterns. The Toll-Like Receptor (TLR) family is well-studied, but more recently another family in the cytoplasmic compartment, called nod-like receptor (NLR), was discovered. In addition to being present in inflammatory cells, these receptors are widely distributed in various cell types, including renal tissue, where these receptors have an important role in triggering the inflammatory response during renal diseases. This review summarizes the present data regarding the role of TLRs and NLRs in the course and development of various kidney pathologies.

引用

页码：428 / 435

页数：8

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