Increased saliva cortisol awakening response in patients with mild cognitive impairment

被引:34
作者
Lind, Karin [1 ]
Edman, Ake
Nordlund, Arto
Olsson, Tommy
Wallin, Anders
机构
[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, SE-43180 Molndal, Sweden
[2] Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden
关键词
hypothalamic-pituitary-adrenal axis; cortisol; cortisol awakening response; dexamethasone; mild cognitive impairment; dementia;
D O I
10.1159/000109938
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: It is unknown whether HPA-axis dysfunction is present in patients with mild cognitive impairment (MCI). The aim of the present study was to investigate whether cortisol levels are elevated among patients with MCI and/or whether the individuals have adequate feedback control of their HPA axis. Material and Methods: 27 patients with MCI and 15 healthy controls were included in the study. Saliva samplings were performed 5 times a day before intake of 0.5 mg dexamethasone, and 5 times a day after intake of dexamethasone, respectively. Results: Significantly higher cortisol levels were found 15 min after awakening among patients with MCI in comparison with the controls, both before and after dexamethasone administration (p < 0.05). Also, the ratio between cortisol at awakening time and 15 min after awakening was lower in the patient group after dexamethasone administration (p < 0.05). There were no significant differences in basal cortisol levels before or after dexamethasone between groups. Conclusion: The results indicate that there is an HPA-axis disturbance, with normal basal cortisol levels and increased awakening response among patients with MCI. The dissociation between basal values and the awakening response may be of pathophysiological importance for the cognitive impairment. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码:389 / 395
页数:7
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