Cyclic sulfamidates as precursors to alkylidene pyrrolidines and piperidines

被引：30
作者：
Bower, John F.
Szeto, Peter
Gallagher, Timothy
机构：
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
[2] GlaxoSmithKline, Med Res Ctr, Synth Chem, Stevenage SG1 2NY, Herts, England
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 23期
关键词：
D O I：
10.1021/ol7022104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of the dienolate of ethyl acetoacetate (and related dienolates) with a range of 1,2- and 1,3-cyclic sulfamidates provides an entry to substituted and enantiopure alkylidenated pyrrolidines and piperidines. These heterocycles function as convenient precursors to heterocyclic beta-amino acid derivatives.
引用
收藏
页码：4909 / 4912
页数：4
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