Identification of novel adenovirus genotype 90 in children from Bangladesh

被引：15

作者：

Houldcroft, Charlotte J. ^{[1
]}

Beale, Mathew A. ^{[2
]}

Abu Sayeed, Md ^{[3
]}

Qadri, Firdausi ^{[3
]}

Dougan, Gordon ^{[1
]}

Mutreja, Ankur ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge, England

[2] Wellcome Sanger Inst, Hinxton, Cambs, England

[3] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh

来源：

MICROBIAL GENOMICS | 2018年 / 4卷 / 10期

基金：

英国惠康基金;

关键词：

adenovirus; DNA virus; metagenomics; diarrhoeal disease; de novo assembly; whole-genome sequencing; ACUTE RESPIRATORY-DISEASE; DIARRHEAL FECES; RECOMBINANT; PATHOGEN; GENERATION; CANDIDATE; DISCOVERY; SEQUENCE; MUTATION; ILLNESS;

D O I：

10.1099/mgen.0.000221

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Novel adenovirus genotypes are associated with outbreaks of disease, such as acute gastroenteritis, renal disease, upper respiratory tract infection and keratoconjunctivitis. Here, we identify novel and variant adenovirus genotypes in children coinfected with enterotoxigenic Escherichia coli, in Bangladesh. Metagenomic sequencing of stool was performed and whole adenovirus genomes were extracted. A novel species D virus, designated genotype 90 (P33H27F67) was identified, and the partial genome of a putative recombinant species B virus was recovered. Furthermore, the enteric types HAdV-A61 and HAdV-A40 were found in stool specimens. Knowledge of the diversity of adenovirus genomes circulating worldwide, especially in low-income countries where the burden of disease is high, will be required to ensure that future vaccination strategies cover the diversity of adenovirus strains associated with disease.

引用

页数：6

共 48 条

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