Physiologic role of interleukin-1 receptor antagonist

被引：83
作者：
Arend, WP
Gabay, C
机构：
[1] Univ Colorado, Hlth Sci Ctr, Div Rheumatol B115, Denver, CO 80262 USA
[2] Univ Hosp Geneva, Div Rheumatol, Geneva, Switzerland
来源：
ARTHRITIS RESEARCH | 2000年 / 2卷 / 04期
关键词：
interleukin-1; interleukin-1 receptor antagonist; rheumatoid arthritis; vasculitis;
D O I：
10.1186/ar94
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit the excess amounts of locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may predispose to local inflammatory disease in particular tissues in the presence of other as yet unknown genetically influenced factors.
引用
收藏
页码：245 / 248
页数：4
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