Fever-Induced Life-Threatening Arrhythmias in Children Harboring an SCN5A Mutation

被引：31

作者：

Chockalingam, Priya ^{[1
]}

Rammeloo, Lukas A. ^{[3
]}

Postema, Pieter G. ^{[1
]}

Hruda, Jarda ^{[3
]}

Clur, Sally-Ann B. ^{[2
]}

Blom, Nico A. ^{[2
]}

Wilde, Arthur A. ^{[1
]}

机构：

[1] Acad Med Ctr, Dept Cardiol, Heart Failure Res Ctr, NL-1105 AZ Amsterdam, Netherlands

[2] Acad Med Ctr, Dept Pediat Cardiol, NL-1105 AZ Amsterdam, Netherlands

[3] Vrije Univ Amsterdam, Med Ctr, Dept Pediat Oncol, Amsterdam, Netherlands

来源：

PEDIATRICS | 2011年 / 127卷 / 01期

关键词：

arrhythmia; children; childhood immunization; fever; SCN5A sodium-channel mutation; INFANT-DEATH-SYNDROME; BRUGADA-SYNDROME; PROLONGATION;

D O I：

10.1542/peds.2010-1688

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Cardiac channelopathies caused by SCN5A mutation are well tolerated by most patients. However, the dramatic presentation of a previously healthy 4-month-old girl with life-threatening arrhythmias and the subsequent findings in the child and her family provide evidence that loss-of-function sodium channel mutations can present very early in life. An SCN5A mutation was detected in the infant, her brother, and their father. Both the siblings manifested recurrent serious arrhythmias during febrile episodes, which followed immunization, as well as fever of nonspecific origin. Management consisted of prompt antipyretic measures, hospitalization with vigorous monitoring during immunization and febrile episodes, and prevention of tachycardia-induced conduction disturbance with beta-blockers. Pediatrics 2011;127:e239-e244

引用

页码：E239 / E244

页数：6

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