A Series of Natural Flavonoids as Thrombin Inhibitors: Structure-activity relationships

被引：90

作者：

Liu, Li ^{[1
]}

Ma, Hongyue ^{[1
]}

Yang, Nianyun ^{[1
]}

Tang, Yuping ^{[1
]}

Guo, Jianming ^{[1
]}

Tao, Weiwei ^{[1
]}

Duan, Jin'ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

来源：

THROMBOSIS RESEARCH | 2010年 / 126卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Flavonoids; Thrombin inhibitors; Structure-activity relationships; STRUCTURE-BASED DESIGN; P1; POSITION; TIME METHOD; R-HIRUDIN; ANTIOXIDANT; SCAFFOLDS; CHEMISTRY; RABBITS; L;

D O I：

10.1016/j.thromres.2010.08.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A series of natural flavonoids has been evaluated as potential inhibitors of thrombin using the optimized method of thrombin time. Myricetin and quercetin have shown to be the best thrombin inhibitors tested. In order to investigate the thrombin recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments. Structure-activity relationships of flavonoids (SARs) on thrombin would facilitate the design of chemical compounds with higher potency to serve as potential thrombin inhibitors, and provide information for the exploitation and utilization of flavonoids as thrombin inhibitors for thrombotic disease treatment. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：E365 / E378

页数：14

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