Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy vs. cytoreductive surgery alone for intrahepatic cholangiocarcinoma with peritoneal metastases: A retrospective cohort study

被引：10

作者：

Feng, Feiling ^{[1
]}

Gao, Qingxiang ^{[1
]}

Wu, Yue ^{[1
]}

Liu, Chen ^{[1
]}

Yu, Yong ^{[1
]}

Li, Bin ^{[1
]}

Chu, Kaijian ^{[1
]}

Yi, Bin ^{[1
]}

Cheng, Qingbao ^{[1
]}

Jiang, Xiaoqing ^{[1
]}

机构：

[1] Eastern Hepatobiliary Surg Hosp, Dept Biliary Tract 1, 225 Changhai Rd, Shanghai 200433, Peoples R China

来源：

EJSO | 2021年 / 47卷 / 09期

关键词：

Intrahepatic cholangiocarcinoma; Cytoreductive surgery; Survival; Prognosis; Hyperthermic intraperitoneal chemotherapy; DIGESTIVE-TRACT CANCER; RADIOFREQUENCY ABLATION; PERFUSION CHEMOTHERAPY; BLADDER-CANCER; BILIARY; HIPEC; CHEMOHYPERTHERMIA; CARCINOMATOSIS; SURVIVAL; THERAPY;

D O I：

10.1016/j.ejso.2021.05.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has survival benefits in patients with intraperitoneal malignant lesions, but there is no study specific to intrahepatic cholangiocarcinoma (ICC). Purpose: To compare the prognosis of patients with advanced ICC undergoing CRS + HIPEC compared with CRS alone. Methods: This study was a retrospective cohort study of patients with advanced ICC treated at the Shanghai Eastern Hepatobiliary Surgery Hospital between 01/2014 and 12/2018. The patients were divided into either CRS + HIPEC or CRS group based on the treatment they received. Overall survival (OS), complications, hospital stay, biochemical indicators, tumor markers, and number of HIPEC were examined. Results: There were 51 and 61 patients in the CRS + HIPEC and CRS groups, respectively. There were no differences between the groups regarding preoperative CA19-9 levels (421 +/- 381 vs. 523 +/- 543 U/mL, P = 0.208). The hospital stay was longer in the CRS + HIPEC group (22.2 +/- 10.0 vs. 18.6 +/- 7.6 days, P = 0.033). The occurrence of overall complications was similar in the two groups (37.2% vs. 34.4%, P = 0.756). The postoperative CA19-9 levels were lower in the CRS + HIPEC group compared with the CRS group (196 +/- 320 vs. 337 +/- 396 U/mL, P = 0.044). The median OS was longer in the CRS + HIPEC group than in the CRS group (25.53 vs. 11.17 months, P < 0.001). Compared with the CRS group, the CRS + HIPEC group showed a higher occurrence of leukopenia (7.8% vs. 0, P = 0.040) but a lower occurrence of total bilirubin elevation (15.7% vs. 37.7%, P = 0.032). Conclusion: CRS + HIPEC could be a treatment option for patients with advanced ICC, with improved OS and similar complications and adverse events compared with CRS alone. (c) 2021 Published by Elsevier Ltd.

引用

页码：2363 / 2368

页数：6

共 47 条

[21] Chemotherapy for intraperitoneal use: a review of hyperthermic intraperitoneal chemotherapy and early post-operative intraperitoneal chemotherapy [J].