Late presentation of HIV infection: a consensus definition

被引:388
作者
Antinori, A. [2 ]
Coenen, T. [3 ]
Costagiola, D. [4 ]
Dedes, N. [5 ]
Ellefson, M. [6 ]
Gatell, J. [7 ]
Girardi, E. [2 ]
Johnson, M. [13 ]
Kirk, O. [6 ]
Lundgren, J. [6 ]
Mocroft, A. [8 ]
Monforte, A. d'Arminio [9 ]
Phillips, A. [8 ]
Raben, D. [1 ,6 ]
Rockstroh, J. K. [10 ]
Sabin, C. [8 ]
Sonnerborg, A. [11 ]
de Wolf, F. [12 ]
机构
[1] Univ Copenhagen, Copenhagen HIV Programme, HIV Europe Secretariat, Panum Inst, DK-2200 Copenhagen N, Denmark
[2] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Rome, Italy
[3] Aids Fonds & Soa Aids Nederland, Amsterdam, Netherlands
[4] INSERM, Paris, France
[5] European AIDS Treatment Grp, Brussels, Belgium
[6] Natl Univ Hosp, Copenhagen, Denmark
[7] Univ Barcelona, Hosp Clin, Clin Inst Med & Dermatol, Barcelona, Spain
[8] UCL, Sch Med, London W1N 8AA, England
[9] San Paolo Hosp, Dept Med, Milan, Italy
[10] Innere Rheuma Tropen Ambulanz, Med Univ Klin, Bonn, Germany
[11] Karolinska Inst, Dept Infect Dis, Stockholm, Sweden
[12] HIV Monitoring Fdn, Amsterdam, Netherlands
[13] Royal Free Hampstead NHS Trust, London, England
基金
瑞典研究理事会;
关键词
definition; diagnosis; Europe; HIV; late presentation; CD4 CELL COUNT; ANTIRETROVIRAL THERAPY; HIV-1-INFECTED PATIENTS; COLLABORATIVE ANALYSIS; LATE DIAGNOSIS; AIDS; RECOMMENDATIONS; CONSEQUENCES; DISEASES; CARE;
D O I
10.1111/j.1468-1293.2010.00857.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objectives Across Europe, almost a third of individuals infected with HIV do not enter health care until late in the course of their infection. Surveillance to identify the extent to which late presentation occurs remains inadequate across Europe and is further complicated by the lack of a common clinical definition of late presentation. The objective of this article is to present a consensus definition of late presentation of HIV infection. Methods Over the past year, two initiatives have moved towards a harmonized definition. In spring 2009, they joined efforts to identify a common definition of what is meant by a 'late-presenting' patient. Results Two definitions were agreed upon, as follows. Late presentation: persons presenting for care with a CD4 count below 350 cells/mu L or presenting with an AIDS-defining event, regardless of the CD4 cell count. Presentation with advanced HIV disease: persons presenting for care with a CD4 count below 200 cells/mL or presenting with an AIDS-defining event, regardless of the CD4 cell count. Conclusion The European Late Presenter Consensus working group believe it would be beneficial if all national health agencies, institutions, and researchers were able to implement this definition ( either on its own or alongside their own preferred definition) when reporting surveillance or research data relating to late presentation of HIV infection.
引用
收藏
页码:61 / 64
页数:4
相关论文
共 26 条
[1]   Late diagnosis of HIV in Europe: definitional and public health challenges [J].
Adler, A. ;
Mounier-Jack, S. ;
Coker, R. J. .
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV, 2009, 21 (03) :284-293
[2]  
[Anonymous], 2009, Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents, P1
[3]   Report of a European Working Group on late presentation with HIV infection: recommendations and regional variation [J].
Antinori, Andrea ;
Johnson, Margaret ;
Moreno, Santiago ;
Yazdanpanah, Yazdan ;
Rockstroh, Juergen K. .
ANTIVIRAL THERAPY, 2010, 15 :31-35
[4]  
*BHIVA, HIV TREATM GUID
[5]   No time to wait: how many HIV-infected homosexual men are diagnosed late and consequently die? (England and Wales, 1993-2002) [J].
Chadborn, TR ;
Baster, K ;
Delpech, VC ;
Sabin, CA ;
Sinka, K ;
Rice, BD ;
Evans, BG .
AIDS, 2005, 19 (05) :513-520
[6]   European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of HIV-infected adults [J].
Clumeck, N. ;
Pozniak, A. ;
Raffi, F. .
HIV MEDICINE, 2008, 9 (02) :65-71
[7]  
*EACS, HIV TREATM GUID 2005
[8]  
*EACS, HIV TREATM GUID 2009
[9]   Prognosis of HIV-1-infected patients starting highly active antiretroviral therapy:: a collaborative analysis of prospective studies [J].
Egger, M ;
May, M ;
Chêne, G ;
Phillips, AN ;
Ledergerber, B ;
Dabis, F ;
Costagliola, D ;
Monforte, AD ;
de Wolf, F ;
Reiss, P ;
Lundgren, JD ;
Justice, AC ;
Staszewski, S ;
Leport, C ;
Hogg, RS ;
Sabin, CA ;
Gill, MJ ;
Salzberger, B ;
Sterne, JAC .
LANCET, 2002, 360 (9327) :119-129