Distinct functional elements for outer-surface anti-interference and inner-wall ion gating of nanochannels

被引：149

作者：

Gao, Pengcheng ^{[1
]}

Ma, Qun ^{[1
]}

Ding, Defang ^{[1
]}

Wang, Dagui ^{[1
]}

Lou, Xiaoding ^{[1
]}

Zhai, Tianyou ^{[2
]}

Xia, Fan ^{[1
]}

机构：

[1] China Univ Geosci, Fac Mat Sci & Chem, Engn Res Ctr Nano Geomat, Minist Educ, 388 Iumo Rd, Wuhan 430074, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Hubei, Peoples R China

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

NANOPORE; DNA; CHANNEL; OLIGONUCLEOTIDES; MEMBRANES; PROTEIN; DISCRIMINATION; TRANSLOCATION; TRANSPORT; COMPLEX;

D O I：

10.1038/s41467-018-06873-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Over the decades, widespread advances have been achieved on nanochannels, including nanochannel-based DNA sequencing, single-molecule detection, smart sensors, and energy transfer and storage. However, most interest has been focused on the contribution from the functional elements (FEs) at the inner wall (IW) of nanochannels, whereas little attention has been paid to the contribution from the FEs at the nanochannels' outer surface (OS). Herein, we achieve explicit partition of FEOS and FEIW based on accurate regional-modification of OS and IW. The FEIW are served for ionic gating, and the chosen FEOS (hydrophobic or charged) are served for blocking interference molecules into the nanochannels, decreasing the false signals for the ionic gating in complex environments. Furthermore, we define a composite factor, areas of a radar map, to evaluate the FEOS performance for blocking interference molecules.

引用

页数：11

共 51 条

[1] The molecular architecture of the nuclear pore complex [J].