Role of dysregulated apoptosis in atopic dermatitis

被引:23
作者
Trautmann, A [1 ]
Akdis, M [1 ]
Blaser, K [1 ]
Akdis, CA [1 ]
机构
[1] Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland
关键词
T cells; keratinocytes; eosinophils; eczematous dermatitis; eczema;
D O I
10.1023/A:1009620329213
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Atopic dermatitis is a chronic inflammatory skin disease with a complex immune dysregulation and interplay of genetic, environmental and psychological factors. Activation and skin-selective homing of peripherial-blood T cells, and effector functions in the skin, represent sequential events in the pathogenesis. Dysregulated apoptosis in skin-homing T cells, eosinophils and keratino-cytes contributes to the elicitation and persistence of atopic derrmatitis.
引用
收藏
页码:425 / 429
页数:5
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