Regulation of synaptic connectivity by glia

被引：582

作者：

Eroglu, Cagla ^{[1
]}

Barres, Ben A. ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[2] Stanford Univ, Med Ctr, Dept Neurobiol, Stanford, CA 94305 USA

来源：

NATURE | 2010年 / 468卷 / 7321期

关键词：

OLIGODENDROCYTE PRECURSOR CELLS; DENDRITIC SPINE MORPHOLOGY; LONG-TERM DEPRESSION; D-SERINE; DROSOPHILA METAMORPHOSIS; NEUROMUSCULAR-JUNCTION; ENGULFMENT RECEPTOR; GLUTAMATE TRANSPORT; CNS SYNAPTOGENESIS; SUPRAOPTIC NUCLEUS;

D O I：

10.1038/nature09612

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human brain contains more than 100 trillion (10(14)) synaptic connections, which form all of its neural circuits. Neuroscientists have long been interested in how this complex synaptic web is weaved during development and remodelled during learning and disease. Recent studies have uncovered that glial cells are important regulators of synaptic connectivity. These cells are far more active than was previously thought and are powerful controllers of synapse formation, function, plasticity and elimination, both in health and disease. Understanding how signalling between glia and neurons regulates synaptic development will offer new insight into how the nervous system works and provide new targets for the treatment of neurological diseases.

引用

页码：223 / 231

页数：9

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