Fatal Reactivation of Occult Hepatitis B Virus Infection after Rituximab and Chemotherapy in Lymphoma: Necessity of Antiviral Prophylaxis

被引：14

作者：

Zhang, Beibei ^{[1
]}

Wang, Junxue ^{[1
]}

Xu, Wensheng ^{[1
]}

Wang, Lei ^{[1
]}

Ni, Wu ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Dept Infect Dis, Shanghai 200003, Peoples R China

来源：

ONKOLOGIE | 2010年 / 33卷 / 10期

关键词：

Hepatitis B Virus; Reactivation; Rituximab; Chemotherapy; Lymphoma;

D O I：

10.1159/000319696

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The anti-CD20 monoclonal antibody rituximab has been used extensively in the treatment of B-cell lymphoma. However, several studies reported hepatitis B virus (HBV) reactivation after rituximab administration. The majority of these cases have been described in chronic carriers of HBV, whereas reactivation in occult hepatitis B carriers is relatively rare. We report a fatal case of fulminant hepatitis B that occurred in a B-cell lymphoma patient with occult hepatitis B after rituximab-containing chemotherapy, which raised the necessity of antiviral prophylaxis in this setting.

引用

页码：537 / 539

页数：3

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