High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction

被引：149

作者：

Kumar, Arnav ^{[1
]}

Thompson, Elizabeth W. ^{[1
]}

Lefieux, Adrien ^{[1
,2
]}

Molony, David S. ^{[1
]}

Davis, Emily L. ^{[1
]}

Chand, Nikita ^{[1
]}

Fournier, Stephane ^{[3
]}

Lee, Hee Su ^{[1
]}

Suh, Jon ^{[1
]}

Sato, Kimi ^{[4
]}

Ko, Yi-An ^{[5
]}

Molloy, Daniel ^{[1
]}

Chandran, Karthic ^{[1
]}

Hosseini, Hossein ^{[1
]}

Gupta, Sonu ^{[1
]}

Milkas, Anastasios

Gogas, Bill ^{[1
]}

Chang, Hyuk-Jae ^{[6
]}

Min, James K. ^{[6
]}

Fearon, William F. ^{[7
,8
]}

Veneziani, Alessandro ^{[9
,10
]}

Giddens, Don P. ^{[9
,10
]}

King, Spencer B., III ^{[1
]}

De Bruyne, Bernard ^{[5
]}

Samady, Habib ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Andreas Gruentzig Cardiovasc Ctr, 1364 Clifton Rd,Suite F606, Atlanta, GA 30322 USA

[2] Emory Univ, Dept Math & Comp Sci, Atlanta, GA 30322 USA

[3] Cardiovasc Ctr, Aalst, Belgium

[4] Univ Tsukuba, Cardiovasc Div, Tsukuba, Ibaraki, Japan

[5] Emory Univ, Rollins Sch Publ Hlth, Dept Biostatist & Bioinformat, Atlanta, GA 30322 USA

[6] Weill Cornell Med, Dept Radiol, New York, NY USA

[7] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[8] Stanford Univ, Sch Med, Div Cardiovasc Med, Stanford, CA 94305 USA

[9] Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[10] Emory Univ, Atlanta, GA 30322 USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2018年 / 72卷 / 16期

基金：

美国国家卫生研究院;

关键词：

fractional flow reserve; high wall shear stress; proximal segment; stable coronary artery disease; vessel-related myocardial infarction; FRACTIONAL FLOW RESERVE; COMPUTATIONAL FLUID-DYNAMICS; INTRAVASCULAR ULTRASOUND; ATHEROSCLEROTIC PLAQUES; NATURAL-HISTORY; MEDICAL THERAPY; GUIDED PCI; FOLLOW-UP; PROGRESSION; BIFURCATION;

D O I：

10.1016/j.jacc.2018.07.075

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress (WSS) has been linked with increased plaque vulnerability. OBJECTIVES This study investigated the prognostic value of WSS measured in the proximal segments of lesions (WSSprox) to predict myocardial infarction (MI) in patients with stable coronary artery disease (CAD) and hemodynamically significant lesions. The authors hypothesized that in patients with low FFR and stable CAD, higher WSSprox would predict MI. METHODS Among 441 patients in the FAME II (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation II) trial with FFR <= 0.80 who were randomized to medical therapy alone, 34 (8%) had subsequent MI within 3 years. Patients with vessel-related MI and adequate angiograms for 3-dimensional reconstruction (n = 29) were propensity matched to a control group with no MI (n = 29) by using demographic and clinical variables. Coronary lesions were divided into proximal, middle, and distal, along with 5-mm upstream and downstream segments. WSS was calculated for each segment. RESULTS Median age was 62 years, and 46 (79%) were male. In the marginal Cox model, whereas lower FFR showed a trend (hazard ratio: 0.084; p = 0.064), higher WSSprox (hazard ratio: 1.234; p = 0.002, C-index = 0.65) predicted MI. Adding WSSprox to FFR resulted in a significant increase in global chi-square for predicting MI (p = 0.045), a net reclassification improvement of 0.69 (p = 0.005), and an integrated discrimination index of 0.11 (p = 0.010). CONCLUSIONS In patients with stable CAD and hemodynamically significant lesions, higher WSS in the proximal segments of atherosclerotic lesions is predictive of MI and has incremental prognostic value over FFR. (C) 2018 by the American College of Cardiology Foundation.

引用

页码：1926 / 1935

页数：10

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