Pathological aspects of lipid peroxidation

被引：360

作者：

Negre-Salvayre, Anne ^{[1
]}

Auge, Nathalie ^{[1
]}

Ayala, Victoria ^{[2
]}

Basaga, Huveyda ^{[3
]}

Boada, Jordi ^{[2
]}

Brenke, Rainer ^{[4
]}

Chapple, Sarah ^{[5
]}

Cohen, Guy ^{[6
]}

Feher, Janos ^{[7
]}

Grune, Tilman ^{[8
]}

Lengyel, Gabriella ^{[7
]}

Mann, Giovanni E. ^{[5
]}

Pamplona, Reinald ^{[2
]}

Poli, Giuseppe ^{[9
]}

Portero-Otin, Manuel ^{[2
]}

Riahi, Yael ^{[6
]}

Salvayre, Robert ^{[1
]}

Sasson, Shlomo ^{[6
]}

Serrano, Jose ^{[2
]}

Shamni, Ofer ^{[6
]}

Siems, Werner ^{[10
]}

Siow, Richard C. M. ^{[5
]}

Wiswedel, Ingrid ^{[11
]}

Zarkovic, Kamelija ^{[12
]}

Zarkovic, Neven ^{[13
]}

机构：

[1] INSERM I2MR 858, IFR 150, Ave J Poulhes,BP 84225, F-31432 Toulouse 4, France

[2] Univ Lleida, Dept Expt Med, Fac Med, E-25008 Lleida, Spain

[3] Sabanci Univ, Biol Sci & Bioengn Program, Fac Engn & Nat Sci, Istanbul, Turkey

[4] Hufeland Hosp, D-56130 Bad Ems, Germany

[5] Kings Coll London, Div Cardiovasc, Sch Med, London WC2R 2LS, England

[6] Hebrew Univ Jerusalem, Sch Pharm, Dept Pharmacol, Inst Drug Res,Fac Med, IL-91120 Jerusalem, Israel

[7] Semmelweis Univ, Fac Med, Dept Med 2, H-1088 Budapest, Hungary

[8] Univ Hohenheim, Inst Biol Chem & Nutr, Dept Biofunct & Food Safety, D-70593 Stuttgart, Germany

[9] Univ Turin, Dept Clin & Biol Sci, San Luigi Hosp, I-10043 Turin, Italy

[10] KortexMed Inst Med Educ Bad Harzburg, Res Inst Physiotherapy & Gerontol, D-38667 Bad Harzburg, Germany

[11] Otto Von Guericke Univ, Dept Pathol Biochem, Fac Med, D-39120 Magdeburg, Germany

[12] Univ Zagreb, Sch Med, Dept Neuropathol, Clin Hosp Ctr Zagreb, Zagreb 10000, Croatia

[13] Rudjer Boskovic Inst, HR-10000 Zagreb, Croatia

来源：

FREE RADICAL RESEARCH | 2010年 / 44卷 / 10期

关键词：

Oxidative stress; oxidative homeostasis; reactive oxygen species; lipid peroxidation; 4-Hydroxynonenal; neurodegenerative diseases; Alzheimer's disease; amyotrophic lateral sclerosis; Parkinson's disease; liver disease; fatty liver; atherosclerosis; redox equilibrium; cell signalling; oxidized phospholipids; oxysterol; diabetes; diabetes complications; 4-hydroxydodecadienal; 4-hydroxynonenal; pre-eclampsia; HELLP syndrome; IUGR; glutathione; redox signaling; Nrf2; antioxidant enzymes; foetal endothelium; renal diseases; lymphoedema; hyperglycaemia; advanced glycation end-products; cancer; SMOOTH-MUSCLE-CELLS; LOW-DENSITY-LIPOPROTEIN; NF-KAPPA-B; AMYOTROPHIC-LATERAL-SCLEROSIS; OXIDATIVE DNA-DAMAGE; PLATELET-ACTIVATING-FACTOR; HUMAN ENDOTHELIAL-CELLS; FREE-RADICAL THEORY; NATURAL PROTECTIVE MECHANISM; UNCOUPLING PROTEIN-3 CONTENT;

D O I：

10.3109/10715762.2010.498478

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New data and literature review are provided evaluating the role of LPO in the pathophysiology of ageing and classically oxidative stress-linked diseases, such as neurodegenerative diseases, diabetes and atherosclerosis (the main cause of cardiovascular complications). Striking evidences implicating LPO in foetal vascular dysfunction occurring in pre-eclampsia, in renal and liver diseases, as well as their role as cause and consequence to cancer development are addressed.

引用

页码：1125 / 1171

页数：47

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