New Sesquiterpenes from Erigeron annus

被引：60

作者：

Li, X ^{[1
]}

Yang, M ^{[1
]}

Han, YF ^{[1
]}

Gao, K ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

PLANTA MEDICA | 2005年 / 71卷 / 03期

关键词：

Erigeron annus; compositae; eudesmane; sesquiterpenes; anti-tumor activity;

D O I：

10.1055/s-2005-837827

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new and five known eudesmane-type sesquiterpenes were isolated from the aerial parts of Erigeron annus. The structures of these new compounds were elucidated by spectral means, including 2D-NMR analysis, to be 1 beta,4 beta-dihydroxyeudesman-11-ene; 1 beta,7 alpha-dihydroxyeudesman-4(15)-ene; (1R,5S,6S,7S,10R)-1 beta, 6 alpha-dihydroxyeudesman-4-one and 1 beta-D-glucopyranosyloxy-6 alpha-hydroxyeudesman-4(15)-ene. In addition, a chemical transformation of a known compound 1 beta,6 alpha-dihydroxy-eudesman-4 (15)-ene was carried out and the derivative 1 beta,6 alpha-dihydroxy-4 beta(15)-epoxyeudesmane was obtained. Some of the compounds were evaluated for their in vitro antitumor activities.

引用

页码：268 / 272

页数：5

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