Prognostic impact of autoimmune disease in oral cavity squamous cell carcinoma

被引：3
作者：
Pillai, Anjali [1 ]
Valero, Cristina [1 ]
Zanoni, Daniella [1 ]
Navas, Kathleen [1 ]
Morris, Quaid [1 ]
Ganly, Ian [1 ]
Patel, Snehal G. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Head & Neck Serv, 1275 York Ave, New York, NY 10065 USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2022年 / 126卷 / 07期
关键词：
autoimmune disease; head and neck cancer; immune dysregulation; inflammatory response; oral squamous cell carcinoma; RISK-FACTORS; NECK-CANCER; HEAD; COHORT; MALIGNANCIES; SCLEROSIS; SPECTRUM; PATIENT;
D O I：
10.1002/jso.27017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background and Objectives Recent literature has highlighted the role of the host in the prognosis of oral squamous cell carcinoma (OSCC). In this study, we retrospectively examined the impact of autoimmune (AI) disorders as an aspect of the host status on survival outcomes in OSCC patients. Methods From a departmental database of OSCC patients (n = 1369), 123 patients with an AI disorder were identified. AI and no-AI groups were compared for survival outcomes. Results There were no significant differences in survival between groups for overall survival, disease-specific survival, local, regional, and distant recurrence-free probabilities. However, survival and recurrence-free probabilities were poorer in the AI group versus the no AI group. Conclusion Patients with AI disease trended towards worse outcomes. This suggests immune dysregulation in these patients may impact oncologic outcomes.
引用
收藏
页码：1183 / 1190
页数：8
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