Cutaneous extranodal NK/T-cell lymphoma: a clinicopathologic study of 5 patients with array-based comparative genomic hybridization

被引：42
作者：
Berti, Emilio [1 ]
Recalcati, Sebastiano [2 ]
Girgenti, Valentina [2 ]
Fanoni, Daniele [2 ]
Venegoni, Luigia [2 ]
Vezzoli, Pamela [2 ]
机构：
[1] Univ Milano Bicocca, Milan, Italy
[2] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin,UO Dermatol, Dipartimento Anestesiol Terapia Intens & Sci Derm, Milan, Italy
来源：
BLOOD | 2010年 / 116卷 / 02期
关键词：
NASAL-TYPE; T-CELL; PROGNOSTIC-FACTORS; TRANSPLANTATION; CLASSIFICATION; ORGANIZATION; NEOPLASMS; LEUKEMIA; SKIN;
D O I：
10.1182/blood-2009-11-252957
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Extranodal natural killer/T-cell (ENK/T) lymphoma is a rare neoplasm, subcategorized into ENK/T-nasal (ENK/T-N) and ENK/T-nasal type (ENK/T-NT) lymphomas. ENK/T-NT lymphoma with initial presentation in the skin is known as primary cutaneous ENK/T-NT (PC-ENK/T-NT) lymphoma. The aim of this study was to investigate pathogenesis, genomic alterations, and prognosis of cutaneous ENK/T lymphomas to provide further insights into clinicopathologic features and genetic mechanism of lymphomagenesis. A retrospective case study of 5 white patients affected by ENK/T lymphoma (4 PC-ENK/T-NT and 1 ENK/T-N with cutaneous involvement) was performed. Most of the cases presented with multiple nodules and ulcerations localized on the extremities. A considerable percentage had disease in advanced stage with a 12-month survival rate of 40%. Genomic alterations were detected by array-based comparative genomic hybridization that showed gains of 1q, 7q and loss of 17p in the cases of PC-ENK/T-NT lymphomas and gain of 7q and loss of 9p, 12p, 12q in the case of ENK/T-N lymphoma. In conclusion, ENK/T lymphoma is a very aggressive entity, and, in our cases, the exclusively cutaneous presentation was not associated with a better prognosis. The results of our array comparative genomic hybridization analysis could be useful to better define the different ENK/T lymphoma subgroups with cutaneous involvement. (Blood. 2010; 116(2): 165-170)
引用
收藏
页码：165 / 170
页数：6
相关论文
共 29 条
[1]   Epidemiology of the non-Hodgkin's lymphomas: Distributions of the major subtypes differ by geographic locations [J].
Anderson, JR ;
Armitage, JO ;
Weisenburger, DD .
ANNALS OF ONCOLOGY, 1998, 9 (07) :717-720
[2]   CD56-positive haematological neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer [J].
Assaf, Chalid ;
Gellrich, Sylke ;
Whittaker, Sean ;
Robson, Alistair ;
Cerroni, Lorenzo ;
Massone, Cesare ;
Kerl, Helmut ;
Rose, Christian ;
Chott, Andreas ;
Chimenti, Sergio ;
Hallermann, Christian ;
Petrella, Tony ;
Wechsler, Janine ;
Bagot, Martine ;
Hummel, Michael ;
Bullani-Kerl, Katrin ;
Bekkenk, Marcel W. ;
Kempf, Werner ;
Meijer, Chris J. L. M. ;
Willemze, Rein ;
Sterry, Wolfram .
JOURNAL OF CLINICAL PATHOLOGY, 2007, 60 (09) :981-989
[3]   Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project [J].
Au, Wing-yan ;
Weisenburger, Dennis D. ;
Intragumtornchai, Tanin ;
Nakamura, Shigeo ;
Kim, Won-Seog ;
Sng, Ivy ;
Vose, Julie ;
Armitage, James O. ;
Liang, Raymond .
BLOOD, 2009, 113 (17) :3931-3937
[4]   Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years [J].
Au, WY ;
Ma, SY ;
Chim, CS ;
Choy, C ;
Loong, F ;
Lie, AKW ;
Lam, CCK ;
Leung, AYH ;
Tse, E ;
Yau, CC ;
Liang, R ;
Kwong, YL .
ANNALS OF ONCOLOGY, 2005, 16 (02) :206-214
[5]  
CARBONE PP, 1971, CANCER RES, V31, P1860
[6]  
Chan JKC., 2008, World health organization classification of tumors: pathology and genetics of tumors of haematopoietic and lymphoid tissues, P285
[7]   Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the International Prognostic Index [J].
Chim, CS ;
Ma, SY ;
Au, WY ;
Choy, C ;
Lie, AKW ;
Liang, R ;
Yau, CC ;
Kwong, YL .
BLOOD, 2004, 103 (01) :216-221
[8]   Extranodal NK/T-cell lymphoma with cutaneous involvement: 'nasal' vs. 'nasal-type' subgroups- a retrospective study of 18 patients [J].
Choi, Y-L. ;
Park, J-H. ;
Namkung, J-H. ;
Lee, J-H. ;
Yang, J-M. ;
Lee, E-S. ;
Lee, D-Y. ;
Jang, K-T. ;
Ko, Y-H. .
BRITISH JOURNAL OF DERMATOLOGY, 2009, 160 (02) :333-337
[9]   INTERNATIONAL PROGNOSTIC INDEX FOR AGGRESSIVE NON-HODGKINS-LYMPHOMA IS VALID FOR ALL MALIGNANCY GRADES [J].
HERMANS, J ;
KROL, ADG ;
VANGRONINGEN, K ;
KLUIN, PM ;
KLUINNELEMANS, JC ;
KRAMER, MHH ;
NOORDIJK, EM ;
ONG, F ;
WIJERMANS, PW .
BLOOD, 1995, 86 (04) :1460-1463
[10]   Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies [J].
Iqbal, J. ;
Kucuk, C. ;
deLeeuw, R. J. ;
Srivastava, G. ;
Tam, W. ;
Geng, H. ;
Klinkebiel, D. ;
Christman, J. K. ;
Patel, K. ;
Cao, K. ;
Shen, L. ;
Dybkaer, K. ;
Tsui, I. F. L. ;
Ali, H. ;
Shimizu, N. ;
Au, W. Y. ;
Lam, W. L. ;
Chan, W. C. .
LEUKEMIA, 2009, 23 (06) :1139-1151
123