Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques

被引：84

作者：

van Dijken, Bart R. J. ^{[1
]}

van Laar, Peter Jan ^{[1
]}

Smits, Marion ^{[2
]}

Dankbaar, Jan Willem ^{[3
]}

Enting, Roelien H. ^{[4
]}

van der Hoorn, Anouk ^{[1
,5
,6
]}

机构：

[1] Univ Med Ctr Groningen, Dept Radiol, Med Imaging Ctr MIC, Groningen, Netherlands

[2] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[3] Univ Med Ctr Utrecht, Dept Radiol, Utrecht, Netherlands

[4] Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

[5] Univ Cambridge, Div Neurosurg, Dept Clin Neurosci, Brain Tumour Imaging Grp, Cambridge, England

[6] Addenbrookes Hosp, Cambridge, England

来源：

JOURNAL OF MAGNETIC RESONANCE IMAGING | 2019年 / 49卷 / 01期

关键词：

glioblastoma; perfusion imaging; magnetic resonance imaging; treatment evaluation; HIGH-GRADE GLIOMAS; CEREBRAL BLOOD-VOLUME; RADIOTHERAPY PLUS CONCOMITANT; INTRAVOXEL INCOHERENT MOTION; SPIN-LABELING PERFUSION; MULTIPARAMETRIC MRI; CONCURRENT CHEMORADIOTHERAPY; RECURRENT GLIOBLASTOMA; COMPUTED-TOMOGRAPHY; RESPONSE ASSESSMENT;

D O I：

10.1002/jmri.26306

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Treatment evaluation of patients with glioblastomas is important to aid in clinical decisions. Conventional MRI with contrast is currently the standard method, but unable to differentiate tumor progression from treatment-related effects. Pseudoprogression appears as new enhancement, and thus mimics tumor progression on conventional MRI. Contrarily, a decrease in enhancement or edema on conventional MRI during antiangiogenic treatment can be due to pseudoresponse and is not necessarily reflective of a favorable outcome. Neovascularization is a hallmark of tumor progression but not for posttherapeutic effects. Perfusion-weighted MRI provides a plethora of additional parameters that can help to identify this neovascularization. This review shows that perfusion MRI aids to identify tumor progression, pseudoprogression, and pseudoresponse. The review provides an overview of the most applicable perfusion MRI methods and their limitations. Finally, future developments and remaining challenges of perfusion MRI in treatment evaluation in neuro-oncology are discussed. Level of Evidence: 3 Technical Efficacy: Stage 4 J. Magn. Reson. Imaging 2019;49:11-22.

引用

页码：11 / 22

页数：12

共 78 条

[1]

Abbas A.K., 2017, Cellular and Molecular Immunology, V9th, P1

[2] Response Assessment in Neuro-Oncology working group and European Association for Neuro-Oncology recommendations for the clinical use of PET imaging in gliomas [J].

Albert, Nathalie L. ;

Weller, Michael ;

Suchorska, Bogdana ;

Galldiks, Norbert ;

Soffietti, Riccardo ;

Kim, Michelle M. ;

La Fougere, Christian ;

Pope, Whitney ;

Law, Ian ;

Arbizu, Javier ;

Chamberlain, Marc C. ;

Vogelbaum, Michael ;

Ellingson, Ben M. ;

Tonn, Joerg C. .

NEURO-ONCOLOGY, 2016, 18 (09) :1199-1208

[3] Recommended Implementation of Arterial Spin-Labeled Perfusion MRI for Clinical Applications: A Consensus of the ISMRM Perfusion Study Group and the European Consortium for ASL in Dementia [J].

Alsop, David C. ;

Detre, John A. ;

Golay, Xavier ;

Guenther, Matthias ;

Hendrikse, Jeroen ;

Hernandez-Garcia, Luis ;

Lu, Hanzhang ;

MacIntosh, Bradley J. ;

Parkes, Laura M. ;

Smits, Marion ;

van Osch, Matthias J. P. ;

Wang, Danny J. J. ;

Wong, Eric C. ;

Zaharchuk, Greg .

MAGNETIC RESONANCE IN MEDICINE, 2015, 73 (01) :102-116

[4] 3D Pseudocontinuous arterial spin labeling in routine clinical practice: A review of clinically significant artifacts [J].

Amukotuwa, Shalini A. ;

Yu, Caroline ;

Zaharchuk, Gregory .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2016, 43 (01) :11-27

[5]

Bagley SJ, 2018, NEURO-ONCOLOGY, P1

[6] Distinguishing Recurrent Intra-Axial Metastatic Tumor from Radiation Necrosis Following Gamma Knife Radiosurgery Using Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging [J].

Barajas, R. F. ;

Chang, J. S. ;

Sneed, P. K. ;

Segal, M. R. ;

McDermott, M. W. ;

Cha, S. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2009, 30 (02) :367-372

[7] Differentiation of Recurrent Glioblastoma Multiforme from Radiation Necrosis after External Beam Radiation Therapy with Dynamic Susceptibility-weighted Contrast-enhanced Perfusion MR Imaging [J].

Barajas, Ramon F., Jr. ;

Chang, Jamie S. ;

Segal, Mark R. ;

Parsa, Andrew T. ;

McDermott, Michael W. ;

Berger, Mitchel S. ;

Cha, Soonmee .

RADIOLOGY, 2009, 253 (02) :486-496

[8] AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients [J].

Batchelor, Tracy T. ;

Sorensen, A. Gregory ;

di Tomaso, Emmanuelle ;

Zhang, Wei-Ting ;

Duda, Dan G. ;

Cohen, Kenneth S. ;

Kozak, Kevin R. ;

Cahill, Daniel P. ;

Chen, Poe-Jou ;

Zhu, Mingwang ;

Ancukiewicz, Marek ;

Mrugala, Maciej M. ;

Plotkin, Scott ;

Drappatz, Jan ;

Louis, David N. ;

Ivy, Percy ;

Scadden, David T. ;

Benner, Thomas ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Jain, Rakesh K. .

CANCER CELL, 2007, 11 (01) :83-95

[9] Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation [J].

Batchelor, Tracy T. ;

Gerstner, Elizabeth R. ;

Emblem, Kyrre E. ;

Duda, Dan G. ;

Kalpathy-Cramer, Jayashree ;

Snuderl, Matija ;

Ancukiewicz, Marek ;

Polaskova, Pavlina ;

Pinho, Marco C. ;

Jennings, Dominique ;

Plotkin, Scott R. ;

Chi, Andrew S. ;

Eichler, April F. ;

Dietrich, Jorg ;

Hochberg, Fred H. ;

Lu-Emerson, Christine ;

Iafrate, A. John ;

Ivy, S. Percy ;

Rosen, Bruce R. ;

Loeffler, Jay S. ;

Wen, Patrick Y. ;

Sorensen, A. Greg ;

Jain, Rakesh K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (47) :19059-19064

[10] Phase III Randomized Trial Comparing the Efficacy of Cediranib As Monotherapy, and in Combination With Lomustine, Versus Lomustine Alone in Patients With Recurrent Glioblastoma [J].

Batchelor, Tracy T. ;

Mulholland, Paul ;

Neyns, Bart ;

Nabors, L. Burt ;

Campone, Mario ;

Wick, Antje ;

Mason, Warren ;

Mikkelsen, Tom ;

Phuphanich, Surasak ;

Ashby, Lynn S. ;

DeGroot, John ;

Gattamaneni, Rao ;

Cher, Lawrence ;

Rosenthal, Mark ;

Payer, Franz ;

Juergensmeier, Juliane M. ;

Jain, Rakesh K. ;

Sorensen, A. Gregory ;

Xu, John ;

Liu, Qi ;

van den Bent, Martin .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (26) :3212-3218

← 1 2 3 4 5 6 7 8 →