At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone

被引：11
作者：
Foley, John [1 ,2 ,3 ]
Nickerson, Nicole [1 ]
Riese, David J., II [4 ]
Hollenhorst, Peter C. [1 ,3 ]
Lorch, Gwendolen [5 ]
Foley, Anne M. [1 ]
机构：
[1] Indiana Univ, Sch Med, Bloomington, IN 47405 USA
[2] Indiana Univ, Sch Med, Dept Dermatol, Indianapolis, IN 46202 USA
[3] Indiana Univ, Sch Med, Simon Canc Ctr, Indianapolis, IN 46202 USA
[4] Auburn Univ, Harrison Sch Pharm, Auburn, AL 36830 USA
[5] Ohio State Univ, Coll Vet Med, Dept Vet Clin Sci, Columbus, OH 43210 USA
来源：
ODONTOLOGY | 2012年 / 100卷 / 02期
关键词：
PTHrP; EGFR; Gene expression; Squamous cell carcinoma; Bone metastasis; Hypercalcemia; EPIDERMAL-GROWTH-FACTOR; HORMONE-RELATED PROTEIN; NONSMALL CELL LUNG; RECEPTOR TYROSINE KINASES; CALCIUM-SENSING RECEPTOR; BREAST-CANCER; NEVER-SMOKERS; HEPARIN-BINDING; GENE-EXPRESSION; FACTOR-ALPHA;
D O I：
10.1007/s10266-012-0070-5
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The epidermal growth factor receptor is a well-established cancer therapeutic target due to its stimulation of proliferation, motility, and resistance to apoptosis. Recently, additional roles for the receptor have been identified in growth of metastases. Similar to development, metastatic spread requires signaling interactions between epithelial-derived tumor cells and mesenchymal derivatives of the microenvironment. This necessitates reactivation of developmental signaling molecules, including the hypercalcemia factor parathyroid hormone-related protein. This review covers the variations of epidermal growth factor receptor signaling in cancers that produce bone metastases, regulation of parathyroid hormone-related protein, and evidence that the two molecules drive cancer-mediated diseases of bone.
引用
收藏
页码：109 / 129
页数：21
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