Synthesis of Protein-Oligonucleotide Conjugates

被引：7

作者：

Watson, Emma E. ^{[1
]}

Winssinger, Nicolas ^{[2
]}

机构：

[1] Univ Adelaide, Sch Phys Sci, Dept Chem, Adelaide, SA 5005, Australia

[2] NCCR Chem Biol, Dept Organ Chem, Fac Sci, CH-1205 Geneva, Switzerland

来源：

BIOMOLECULES | 2022年 / 12卷 / 10期

关键词：

oligonucleotides; proteins; bioconjugation; LIGAND-TARGET PAIRS; DNA NANOSTRUCTURES; NATIVE ANTIBODIES; IDENTIFICATION; LIBRARIES; DESIGN; LOGIC; CELLS;

D O I：

10.3390/biom12101523

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleic acids and proteins form two of the key classes of functional biomolecules. Through the ability to access specific protein-oligonucleotide conjugates, a broader range of functional molecules becomes accessible which leverages both the programmability and recognition potential of nucleic acids and the structural, chemical and functional diversity of proteins. Herein, we summarize the available conjugation strategies to access such chimeric molecules and highlight some key case study examples within the field to showcase the power and utility of such technology.

引用

页数：12

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