The Role of p66shc in Oxidative Stress and Apoptosis

被引：104

作者：

Galimov, E. R. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow, Russia

来源：

ACTA NATURAE | 2010年 / 2卷 / 04期

关键词：

apoptosis; reactive oxygen species; p66shc; mitochondria; LIFE-SPAN; ADAPTER PROTEIN; CYTOCHROME-C; FORKHEAD PROTEINS; GENETIC DELETION; P66(SHC) GENE; CELL-DEATH; PHOSPHORYLATION; REGULATOR; SURVIVAL;

D O I：

10.32607/20758251-2010-2-4-44-51

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p66shc is a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Mice knocked out for p66shc have a lifespan similar to 30% longer and demonstrate an enhanced resistance to oxidative stress and age-related pathologies such as hypercholesterolemia, ischemia, and hyperglycemia. In this respect, p66shc is a promising pharmacological target for the treatment of age-related diseases. In this review, an attempt has been made to survey and put to a critical analysis data concerning the involvement of p66shc in the different signaling pathways that regulate oxidative stress and apoptosis.

引用

页码：44 / 51

页数：8

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