Donor origin of multipotent adult progenitor cells in radiation chimeras

被引：16
作者：
Reyes, M
Li, S
Foraker, J
Kimura, E
Chamberlain, JS [1 ]
机构：
[1] Univ Washington, Sch Med, Dept Neurol, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA
[3] Univ Washington, Sch Med, Dept Biochem, Seattle, WA 98195 USA
[4] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[5] Univ Washington, Sch Med, Muscular Dystrophy Cooperat Res Ctr, Seattle, WA 98195 USA
来源：
BLOOD | 2005年 / 106卷 / 10期
关键词：
D O I：
10.1182/blood-2004-12-4603
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated within the adherent cell component. Numerous studies of bone marrow chimeras in the human and the mouse point to a host origin of bone marrow stromal cells. Mesenchymal stem cells (MSCs), which coexist with stromal cells, have also been proven to be of host origin after allogeneic bone marrow transplantation in numerous studies. We report here that following syngeneic bone marrow transplants into lethally irradiated C57BL6 mice, MAPCs are of donor origin.
引用
收藏
页码：3646 / 3649
页数：4
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