Acute liver failure in neonates

被引：36

作者：

Dhawan, A ^{[1
]}

Mieli-Vergani, G ^{[1
]}

机构：

[1] Kings Coll Hosp London, Variety Club Childrens Hosp, Paediat Liver Ctr, Inst Liver Studies,Kings Coll Sch Med, London SE5 9RS, England

来源：

EARLY HUMAN DEVELOPMENT | 2005年 / 81卷 / 12期

关键词：

neonatal acute liver failure; coagulopathy; herpes simplex virus; metabolic disease; neonatal haemochromatosis; liver transplant;

D O I：

10.1016/j.earlhumdev.2005.10.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Acute liver failure (ALF) in neonates is a rare but often fatal event. Though in adults and older children, a main symptom of ALF is hepatic encephalopathy, this is very difficult to diagnose and prove in infants. Causes of ALF in neonates encompass metabolic, infectious and haematological disorders, congenital vascular/heart abnormalities, and drugs. Infants with ALF should only be treated in specialised paediatric hepatology centres with facilities for liver transplantation, since for many liver transplant, with a long term survival of over 60%, is the only therapeutic option. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1005 / 1010

页数：6

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