Illuminating the functional and structural repertoire of human TBC/ RABGAPs

被引：139

作者：

Frasa, Marieke A. M. ^{[1
]}

Koessmeier, Katja T. ^{[2
]}

Ahmadian, M. Reza ^{[2
]}

Braga, Vania M. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[2] Univ Dusseldorf, Fac Med, Inst Biochem & Mol Biol 2, D-40225 Dusseldorf, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 02期

基金：

英国医学研究理事会;

关键词：

GTPASE-ACTIVATING PROTEIN; EPIDERMAL-GROWTH-FACTOR; RAB GTPASES; GLUT4; TRANSLOCATION; ENDOCYTIC TRAFFICKING; T-CELLS; DOMAIN; GAPS; IDENTIFICATION; MEMBRANE;

D O I：

10.1038/nrm3267

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in different diseases. Importantly, TBC/RABGAPs act as key regulatory nodes, integrating signalling between RABs and other small GTPases and ensuring the appropriate retrieval, transport and delivery of different intracellular vesicles.

引用

页码：67 / 73

页数：7

共 80 条

[51] USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst [J].

Oliveira, AM ;

Hsi, BL ;

Weremowicz, S ;

Rosenberg, AE ;

Dal Cin, P ;

Joseph, N ;

Bridge, JA ;

Perez-Atayde, AR ;

Fletcher, JA .

CANCER RESEARCH, 2004, 64 (06) :1920-1923

[52] Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration [J].

Palamidessi, Andrea ;

Frittoli, Emanuela ;

Garre, Massimiliano ;

Faretta, Mario ;

Mione, Marina ;

Testa, Ilaria ;

Diaspro, Alberto ;

Lanzetti, Letizia ;

Scita, Giorgio ;

Di Fiore, Pier Paolo .

CELL, 2008, 134 (01) :135-147

[53] Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin [J].

Pan, Fan ;

Sun, Luo ;

Kardian, David B. ;

Whartenby, Katharine A. ;

Pardoll, Drew M. ;

Liu, Jun O. .

NATURE, 2007, 445 (7126) :433-436

[54] TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism [J].

Pan, Xiaojing ;

Eathiraj, Sudharshan ;

Munson, Mary ;

Lambright, David G. .

NATURE, 2006, 442 (7100) :303-306

[55] Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation [J].

Patino-Lopez, Genaro ;

Dong, Xiaoyun ;

Ben-Aissa, Khadija ;

Bernot, Kelsie M. ;

Itoh, Takashi ;

Fukuda, Mitsunori ;

Kruhlak, Michael J. ;

Samelson, Lawrence E. ;

Shaw, Stephen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (26) :18323-18330

[56] Insulin-stimulated Phosphorylation of the Rab GTPase-activating Protein TBC1D1 Regulates GLUT4 Translocation [J].

Peck, Grantley R. ;

Chavez, Jose A. ;

Roach, William G. ;

Budnik, Bogdan A. ;

Lane, William S. ;

Karlsson, Hakan K. R. ;

Zierath, Juleen R. ;

Lienhard, Gustav E. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (44) :30016-30023

[57]

Pei L, 2002, CANCER RES, V62, P5420

[58] Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence [J].

Peralta, Eigen R. ;

Martin, Brent C. ;

Edinger, Aimee L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (22) :16814-16821

[59] Regulation of endocytic traffic by Rho GTPases [J].

Qualmann, Britta ;

Mellor, Harry .

Biochemical Journal, 2003, 371 (02) :233-241

[60] Rab conversion as a mechanism of progression from early to late endosomes [J].

Rink, J ;

Ghigo, E ;

Kalaidzidis, Y ;

Zerial, M .

CELL, 2005, 122 (05) :735-749

← 1 2 3 4 5 6 7 8 →