Illuminating the functional and structural repertoire of human TBC/ RABGAPs

被引：139

作者：

Frasa, Marieke A. M. ^{[1
]}

Koessmeier, Katja T. ^{[2
]}

Ahmadian, M. Reza ^{[2
]}

Braga, Vania M. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[2] Univ Dusseldorf, Fac Med, Inst Biochem & Mol Biol 2, D-40225 Dusseldorf, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 02期

基金：

英国医学研究理事会;

关键词：

GTPASE-ACTIVATING PROTEIN; EPIDERMAL-GROWTH-FACTOR; RAB GTPASES; GLUT4; TRANSLOCATION; ENDOCYTIC TRAFFICKING; T-CELLS; DOMAIN; GAPS; IDENTIFICATION; MEMBRANE;

D O I：

10.1038/nrm3267

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in different diseases. Importantly, TBC/RABGAPs act as key regulatory nodes, integrating signalling between RABs and other small GTPases and ensuring the appropriate retrieval, transport and delivery of different intracellular vesicles.

引用

页码：67 / 73

页数：7

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