CAVEOLIN-1 AND BREAST CANCER: A New Clinical Perspective

被引：0

作者：

Mercier, Isabelle ^{[1
]}

Lisanti, Michael P. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Stem Cell Biol & Regenerat Med, Philadelphia, PA 19107 USA

来源：

CAVEOLINS AND CAVEOLAE: ROLES IN SIGNALING AND DISEASE MECHANISMS | 2012年 / 729卷

关键词：

ONCOGENICALLY TRANSFORMED-CELLS; ANCHORAGE-INDEPENDENT GROWTH; STROMAL CAVEOLIN-1; DOWN-REGULATION; TUMOR-GROWTH; MAMMARY TUMORIGENESIS; SCAFFOLDING DOMAIN; GENE FAMILY; FIBROBLASTS; EXPRESSION;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The current chapter focuses on the role of Caveolin-1 (Cav-1) in cellular growth with an emphasis on its implication in breast cancer initiation, progression, clinical prognosis and as a potential therapeutic target. The role of Cav-1 as a tumor suppressor in breast cancer has emerged in the past few years, with dual functions on both cancer epithelium as well as the cancer stroma. Its multiple functions as a regulator of estrogen signaling and kinase activity and its newly found role as an important factor controlling the dynamic relationship between cancer epithelia and stroma position Cav-1 as a new therapeutic target for the treatment of breast cancer.

引用

页码：83 / 94

页数：12

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