Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer

被引：33

作者：

Salatino, Mariana ^{[1
]}

Romina Girotti, Maria ^{[2
]}

Rabinovich, Gabriel A. ^{[1
,2
,3
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, IBYME, Lab Inmunopatol, Vuelta de Obligado 2490,C1428ADN, Buenos Aires, DF, Argentina

[2] Consejo Nacl Invest Cient & Tecn, IBYME, Lab Inmunooncol Traslac, Vuelta de Obligado 2490,C1428ADN, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Intendente Guiraldes 2160,C1428EGA, Buenos Aires, DF, Argentina

来源：

CANCER CELL | 2018年 / 33卷 / 02期

关键词：

GLYCOSYLATION;

D O I：

10.1016/j.ccell.2018.01.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The clinical efficacy of therapies targeting the PD-1/PD-L1 pathway is still limited. In this issue of Cancer Cell, Li and colleagues identify a PD-L1 glycosylation-based mechanism in triple-negative breast cancer that fosters immunosuppression by enhancing interactions with PD-1. Targeting glycosylated PD-L1 with a drug-conjugated antibody opens new avenues for treatment.

引用

页码：155 / 157

页数：4

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