Standardized Flavonoid-Rich Eugenia jambolana Seed Extract Retards In Vitro and In Vivo LDL Oxidation and Expression of VCAM-1 and P-Selectin in Atherogenic Rats

被引：10

作者：

Jadeja, Ravirajsinh N. ^{[1
]}

Thouaojam, Menaka C. ^{[1
]}

Sankhari, Jayantha M. ^{[1
]}

Jain, Mahendra ^{[2
]}

Devkar, Ranjitsinh V. ^{[1
]}

Ramachandran, A. V. ^{[1
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Zool, Div Phytotherapeut & Metab Endocrinol, Baroda 390002, Gujarat, India

[2] Maharaja Sayajirao Univ Baroda, Fac Engn & Technol, Dept Pharm, Herbal Drug Technol Lab, Baroda 390002, Gujarat, India

来源：

CARDIOVASCULAR TOXICOLOGY | 2012年 / 12卷 / 01期

关键词：

Flavonoids; Eugenia jambolana; LDL oxidation; VCAM-1; P-selectin; Macrophages; DENSITY-LIPOPROTEIN; ATHEROSCLEROSIS; CALCIFICATION; DISEASE; KERNEL;

D O I：

10.1007/s12012-011-9140-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present inventory evaluates anti-atherogenic potential of flavonoid-rich Eugenia jambolana seed extract (EJSE) against in vitro low-density lipoprotein (LDL) oxidation, foam cell formation, and atherogenic (ATH) diet-induced experimental atherosclerosis in rats. EJSE was able to prevent in vitro LDL oxidation and oxidized LDL-induced macrophage foam cell formation. Also, EJSE supplementation to ATH rats significantly minimized increment in serum markers of LDL oxidation. The ex vivo oxidation indices were also minimized in LDL of EJSE-treated animals. Microscopic evaluation of thoracic aorta of ATH + EJSE rats recorded minimal evidence of atheromatous plaque formation, accumulation of lipid laden macrophages, calcium deposition, and expression of cell adhesion molecules (vascular cell adhesion molecule-1 and P-selectin). This is the first scientific report that demonstrates anti-atherogenic potential of EJSE and warrants further evaluation at clinical level.

引用

页码：73 / 82

页数：10

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