Enantiodivergent and γ-Selective Asymmetric Allylic Amination

被引：79

作者：

Wang, Jianmin ^{[1
]}

Chen, Jie ^{[1
]}

Kee, Choon Wee ^{[1
]}

Tan, Choon-Hong ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 10期

关键词：

allylic compounds; asymmetric synthesis; homogeneous catalysis; organocatalysis; synthetic methods; ENANTIOSELECTIVE SYNTHESIS; CATALYZED ADDITION; DERIVATIVES;

D O I：

10.1002/anie.201107317

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double agent: The title reaction using the guanidine catalyst 1 can deliver both enantiomers of the product with excellent enantioselectivity by judicious choice of the double bond geometry of the the β,γ-unsaturated carbonyl compound. Computational studies reveal the possible origin of the inversed enantioselectivity, and the potential for enantiodivergent synthesis chiral amine-containing substrates is attractive. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2382 / 2386

页数：5

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