mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia

被引：21

作者：

Brambilla, Claudia Regio ^{[1
,2
]}

Veselinovi, Tanja ^{[2
]}

Rajkumar, Ravichandran ^{[1
,2
,3
]}

Mauler, Jorg ^{[1
]}

Orth, Linda ^{[1
,2
]}

Ruch, Andrej ^{[2
]}

Ramkiran, Shukti ^{[1
,2
]}

Heekeren, Karsten ^{[4
]}

Kawohl, Wolfram ^{[4
]}

Wyss, Christine ^{[4
]}

Kops, Elena Rota ^{[1
]}

Scheins, Jurgen ^{[1
]}

Tellmann, Lutz ^{[1
]}

Boers, Frank ^{[1
]}

Neumaier, Bernd ^{[5
]}

Ermert, Johannes ^{[5
]}

Herzog, Hans ^{[1
]}

Langen, Karl-Josef ^{[1
,3
,6
]}

Shah, N. Jon ^{[1
,3
,7
,8
]}

Lerche, Christoph ^{[1
]}

Neuner, Irene ^{[1
,2
,3
]}

机构：

[1] Forschungszentrum Julich, INM 4, Inst Neurosci & Med, Wilhelm Johnen Str, Julich, Germany

[2] Rhein Westfal TH Aachen, Dept Psychiat Psychotherapy & Psychosomat, Aachen, Germany

[3] JARA BRAIN Translat Med, Aachen, Germany

[4] Univ Hosp Psychiat, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland

[5] Forschungszentrum Julich, INM 5, Inst Neurosci & Med, Wilhelm Johnen Str, Julich, Germany

[6] Rhein Westfal TH Aachen, Dept Nucl Med, Aachen, Germany

[7] Forschungszentrum Julich, INM 11, Inst Neurosci & Med, Julich, Germany

[8] Rhein Westfal TH Aachen, Dept Neurol, Aachen, Germany

来源：

HUMAN BRAIN MAPPING | 2020年 / 41卷 / 10期

关键词：

chronic schizophrenia; cognition; mGluR5; receptor; negative symptoms; positron emission tomography; METABOTROPIC GLUTAMATE RECEPTORS; IN-VIVO VARIATION; WORKING-MEMORY; 5; BINDING; PREFRONTAL CORTEX; PROCESSING SPEED; MISMATCH NEGATIVITY; POSITIVE MODULATORS; PROTEIN EXPRESSION; LOCOMOTOR-ACTIVITY;

D O I：

10.1002/hbm.24976

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, the role of the metabotropic glutamatergic receptors type 5 (mGluR5) in this disease remains unclear. In this study, we investigated their significance (using [C-11]ABP688) for psychopathology and cognition in male patients with chronic schizophrenia and healthy controls. In the patient group, lower mGluR5 binding potential (BPND) values in the left temporal cortex and caudate were associated with higher general symptom levels (negative and depressive symptoms), lower levels of global functioning and worse cognitive performance. At the same time, in both groups, mGluR5 BP(ND)were significantly lower in smokers (F-[27,F-1]= 15.500;p= .001), but without significant differences between the groups. Our findings provide support for the concept that the impaired function of mGluR5 underlies the symptoms of schizophrenia. They further supply a new perspective on the complex relationship between tobacco addiction and schizophrenia by identifying glutamatergic neurotransmission-in particularly mGluR5-as a possible connection to a shared vulnerability.

引用

页码：2762 / 2781

页数：20