Common variants on 8p12 and 1q24.2 confer risk of schizophrenia

被引：194

作者：

Shi, Yongyong ^{[1
,2
,3
]}

Li, Zhiqiang ^{[1
,2
]}

Xu, Qi ^{[4
]}

Wang, Ti ^{[1
]}

Li, Tao ^{[1
]}

Shen, Jiawei ^{[1
]}

Zhang, Fengyu ^{[5
]}

Chen, Jianhua ^{[6
]}

Zhou, Guoquan ^{[3
]}

Ji, Weidong ^{[3
]}

Li, Baojie ^{[1
]}

Xu, Yifeng ^{[6
]}

Liu, Dengtang ^{[6
]}

Wang, Peng ^{[7
]}

Yang, Ping ^{[7
]}

Liu, Benxiu ^{[8
]}

Sun, Wensheng ^{[8
]}

Wan, Chunling ^{[1
]}

Qin, Shengying ^{[1
,2
]}

He, Guang ^{[1
,2
]}

Steinberg, Stacy ^{[9
]}

Cichon, Sven ^{[10
,11
,12
]}

Werge, Thomas ^{[13
]}

Sigurdsson, Engilbert ^{[14
]}

Tosato, Sarah ^{[15
]}

Palotie, Aarno ^{[16
,17
,18
,19
,20
]}

Noethen, Markus M. ^{[10
,11
,21
]}

Rietschel, Marcella ^{[22
,23
]}

Ophoff, Roel A. ^{[24
,25
,26
]}

Collier, David A. ^{[27
]}

Rujescu, Dan ^{[28
]}

St Clair, David ^{[29
]}

Stefansson, Hreinn ^{[9
]}

Stefansson, Kari ^{[9
]}

Ji, Jue ^{[1
]}

Wang, Qingzhong ^{[1
]}

Li, Wenjin ^{[1
]}

Zheng, Linqing ^{[1
]}

Zhang, Hairong ^{[1
]}

Feng, Guoyin ^{[5
]}

He, Lin ^{[1
,2
,30
,31
]}

机构：

[1] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China

[2] Shanghai GenomePilot Inst Genom & Human Hlth, Shanghai, Peoples R China

[3] Changning Mental Hlth Ctr, Shanghai, Peoples R China

[4] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing, Peoples R China

[5] NIMH, Genes Cognit & Psychosis Program, NIH, Bethesda, MD USA

[6] Shanghai Inst Mental Hlth, Shanghai, Peoples R China

[7] Fourth Peoples Hosp, Wuhu, Peoples R China

[8] Longquan Mt Hosp Guangxi Prov, Liuzhou, Peoples R China

[9] deCODE Genet, Reykjavik, Iceland

[10] Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany

[11] Univ Bonn, Inst Human Genet, Bonn, Germany

[12] Res Ctr Juelich, Inst Neurosci & Med INM 1, Struct & Funct Org Brain Genom Imaging, Julich, Germany

[13] Copenhagen Univ Hosp, Inst Biol Psychiat, Mental Hlth Ctr St Hans, Roskilde, Denmark

[14] Natl Univ Hosp Reykjavik, Dept Psychiat, Reykjavik, Iceland

[15] Univ Verona, Sect Psychiat & Clin Psychol, Verona, Italy

[16] Wellcome Trust Sanger Inst, Cambridge, England

[17] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland

[18] Broad Inst MIT & Harvard, Program Med & Populat Genet & Genet Anal Platform, Cambridge, MA USA

[19] Univ Helsinki, Dept Med Genet, Helsinki, Finland

[20] Univ Helsinki, Cent Hosp, Dept Med Genet, Helsinki, Finland

[21] German Ctr Neurodegenerat Disorders, Bonn, Germany

[22] Heidelberg Univ, Dept Genet Epidemiol Psychiat, Cent Inst Mental Hlth, Mannheim, Germany

[23] Univ Bonn, Dept Psychiat, Bonn, Germany

[24] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands

[25] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands

[26] Univ Calif Los Angeles, Ctr Neurobehav Genet, Los Angeles, CA USA

[27] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat, London, England

[28] Ludwig Maximilians Univ Munchen, Dept Psychiat, Div Mol & Clin Neurobiol, Munich, Germany

[29] Univ Aberdeen, Dept Mental Hlth, Royal Cornhill Hosp, Aberdeen, Scotland

[30] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China

[31] Chinese Acad Sci, Inst Nutr Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China

来源：

NATURE GENETICS | 2011年 / 43卷 / 12期

关键词：

GENOME-WIDE ASSOCIATION; LOCI; NUCLEOTIDE; EXPRESSION; MUTATIONS;

D O I：

10.1038/ng.980

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Schizophrenia is a severe mental disorder affecting similar to 1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 individuals with schizophrenia and 6,468 healthy controls (1,578 cases and 1,592 controls from northern Han Chinese, 1,238 cases and 2,856 controls from central Han Chinese, and 934 cases and 2,020 controls from the southern Han Chinese). We further analyzed the strongest association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese population. Meta-analysis identified common SNPs that associated with schizophrenia with genome-wide significance on 8p12 (rs16887244, P = 1.27 x 10(-10)) and 1q24.2 (rs10489202, P = 9.50 x 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia.

引用

页码：1224 / +

页数：6

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