Traceless Solid-Phase Synthesis of Trifluoromethylarenes

被引：21
|
作者：
Doebele, Marion [1 ]
Wiehn, Matthias S. [1 ]
Braese, Stefan [1 ,2 ]
机构：
[1] Inst Organ Chem, D-76131 Karlsruhe, Germany
[2] ComPlat, D-76344 Eggenstein Leopoldshafen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 48期
关键词：
combinatorial chemistry; dithioesters; fluorination; solid-phase synthesis; trifluoromethylation; FACILE SYNTHESIS; THIOL ESTERS; FLUORINE; PALLADIUM; ARYL;
D O I：
10.1002/anie.201105446
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Save the best for last: In the first method for the trifluoromethylation of immobilized arenes, the aryl halides are attached through a dithioester linkage to the Merrifield resin and then functionalized by means of numerous reactions including transition-metal-catalyzed cross-couplings. In the final step the fluorinating cleavage reaction provides the trifluoromethylarenes in good yields and high purities. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11533 / 11535
页数：3
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