Tissue Factor and Atherosclerosis: Not only vessel wall-derived TF, but also platelet-associated TF

被引：31

作者：

Camera, Marina ^{[1
,2
]}

Brambilla, Marta ^{[2
]}

Facchinetti, Laura ^{[2
]}

Canzano, Paola ^{[2
]}

Spirito, Rita ^{[2
]}

Rossetti, Laura ^{[2
]}

Saccu, Claudio ^{[2
]}

Di Minno, Matteo Nicola Dario ^{[3
]}

Tremoli, Elena ^{[1
,2
]}

机构：

[1] Univ Milan, Dept Pharmacol Sci, I-20133 Milan, Italy

[2] Ctr Cardiol Monzino IRCCS, I-20138 Milan, Italy

[3] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy

来源：

THROMBOSIS RESEARCH | 2012年 / 129卷 / 03期

关键词：

Tissue Factor; atherosclerosis; platelets; FACTOR PATHWAY INHIBITOR; FACTOR EXPRESSION; FACTOR GENE; PLAQUE THROMBOGENICITY; MYOCARDIAL-INFARCTION; COAGULATION; CDNA; LOCALIZATION; RISK; ATHEROTHROMBOSIS;

D O I：

10.1016/j.thromres.2011.11.028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In the last ten years the contribution of both vessel wall-derived tissue factor (TF) and platelets to atherosclerosis has been revisited. At the beginning of the 2000 a circulating blood-borne TF has been proposed to sustain coagulation activation and propagation on the edge of a growing thrombus. Concomitantly with the observation that platelets not only contribute to thrombus formation, but also take part to the onset of the atherosclerotic lesion, evidences have been provided that they express functionally active TF, making them able to trigger the coagulation cascade. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：279 / 284

页数：6

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