The emerging threat of artemisinin resistance in malaria: focus on artemether-lumefantrine

被引：13
作者：
Djimde, Abdoulaye A. [1 ]
Makanga, Michael [2 ]
Kuhen, Kelli [3 ]
Hamed, Kamal [4 ]
机构：
[1] Univ Sci Tech & Technol Bamako, Malaria Res & Training Ctr, Bamako, Mali
[2] European & Developing Countries Clin Trials Partn, Cape Town, South Africa
[3] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA
[4] Novartis Pharmaceut, E Hanover, NJ 07936 USA
来源：
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2015年 / 13卷 / 08期
关键词：
artemether-lumefantrine; artemisinin resistance; clinical efficacy; molecular markers; systematic review; PLASMODIUM-FALCIPARUM MALARIA; ARTESUNATE PLUS AMODIAQUINE; PFMDR1 COPY NUMBER; IN-VIVO EFFICACY; ANTIMALARIAL-DRUG RESISTANCE; VITRO-REDUCED SUSCEPTIBILITY; FIXED-DOSE COMBINATION; THAN; YEARS; UNCOMPLICATED MALARIA; DIHYDROARTEMISININ-PIPERAQUINE;
D O I：
10.1586/14787210.2015.1052793
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The development of artemisinin resistance in the Greater Mekong Subregion poses a significant threat to malaria elimination. Artemisinin-based combination therapies including artemether-lumefantrine (AL) are recommended by WHO as first-line treatment for uncomplicated Plasmodium falciparum malaria. This article provides a comprehensive review of the existing and latest data as a basis for interpretation of observed variability in parasite sensitivity to AL over the last 5 years. Clinical efficacy and preclinical data from a range of endemic countries are summarized, including potential molecular markers of resistance. Overall, AL remains effective in the treatment of uncomplicated P. falciparum malaria in most regions. Establishing validated molecular markers for resistance and strict efficacy monitoring will reinforce timely updates of treatment policies.
引用
收藏
页码：1031 / 1045
页数：15
相关论文
共 184 条
[51]   Multicentre study evaluating the non-inferiority of the new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal [J].
Faye, Babacar ;
Kuete, Thomas ;
Kiki-Barro, Christiane P. ;
Tine, Roger C. ;
Nkoa, Therese ;
Ndiaye, Jean Louis A. ;
Kakpo, Claude A. ;
Sylla, Khadime ;
El Menan, Herve ;
Gaye, Oumar ;
Faye, Oumar ;
Same-Ekobo, Albert ;
Moussa, Kone .
MALARIA JOURNAL, 2012, 11
[52]   Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) versus artemether-lumefantrine (Coartem®) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast [J].
Faye, Babacar ;
Offianan, Andre Toure ;
Ndiaye, Jean Louis ;
Tine, Roger Clement ;
Toure, Walatchin ;
Djoman, Kali ;
Sylla, Khadime ;
Ndiaye, Paulette Suzanne ;
Penali, Louis ;
Gaye, Oumar .
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2010, 15 (05) :608-613
[53]   A Randomized Trial of Artesunate Mefloquine versus Artemether Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Senegalese Children [J].
Faye, Babacar ;
Ndiaye, Jean Louis ;
Tine, Roger ;
Sylla, Khadim ;
Gueye, Ali ;
Lo, Aminata Colle ;
Gaye, Oumar .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 82 (01) :140-144
[54]   Increased pfmdr1 Copy Number and Sequence Polymorphisms in Plasmodium falciparum Isolates from Sudanese Malaria Patients Treated with Artemether-Lumefantrine [J].
Gadalla, Nahla B. ;
Adam, Ishag ;
Elzaki, Salah-Eldin ;
Bashir, Sahar ;
Mukhtar, Izdihar ;
Oguike, Mary ;
Gadalla, Amal ;
Mansour, Fathi ;
Warhurst, David ;
El-Sayed, Badria B. ;
Sutherland, Colin J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (11) :5408-5411
[55]   Oral Artesunate-Amodiaquine and Artemether-Lumefantrine in the Treatment of Uncomplicated Hyperparasitaemic Plasmodium falciparum Malaria in Children [J].
Gbotosho, Grace O. ;
Sowunmi, Akintunde ;
Okuboyejo, Titilope M. ;
Happi, Christian T. .
JOURNAL OF TROPICAL PEDIATRICS, 2012, 58 (02) :151-153
[56]   A Simple Dose Regimen of Artesunate and Amodiaquine Based on Age or Body Weight Range for Uncomplicated Falciparum Malaria in Children: Comparison of Therapeutic Efficacy With Standard Dose Regimen of Artesunate and Amodiaquine and Artemether-Lumefantrine [J].
Gbotosho, Grace O. ;
Sowunmi, Akintunde ;
Okuboyejo, Titilope M. ;
Happi, Christian T. ;
Folarin, Onikepe O. ;
Adewoye, Elsie O. .
AMERICAN JOURNAL OF THERAPEUTICS, 2012, 19 (04) :E122-E131
[57]   Therapeutic Efficacies of Artemisinin-Based Combination Therapies in Nigerian Children with Uncomplicated Falciparum Malaria during Five Years of Adoption as First-Line Treatments [J].
Gbotosho, Grace O. ;
Sowunmi, Akintunde ;
Happi, Christian T. ;
Okuboyejo, Titilope M. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2011, 84 (06) :936-943
[58]   Therapeutic Efficacy and Effects of Artemether-Lumefantrine and Artesunate-Amodiaquine Coformulated or Copackaged on Malaria-Associated Anemia in Children with Uncomplicated Plasmodium falciparum Malaria in Southwest Nigeria [J].
Gbotosho, Grace O. ;
Sowunmi, Akintunde ;
Okuboyejo, Titilope M. ;
Happi, Christian T. ;
Folarin, Onikepe A. ;
Michael, Obaro S. ;
Adewoye, Elsie O. .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2011, 84 (05) :813-819
[59]   High prevalence of pfcrt-CVIET haplotype in isolates from asymptomatic and symptomatic patients in south-central Oromia, Ethiopia [J].
Golassa, Lemu ;
Enweji, Nizar ;
Erko, Berhanu ;
Aseffa, Abraham ;
Swedberg, Gote .
MALARIA JOURNAL, 2014, 13
[60]   Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia [J].
Gosi, Panita ;
Lanteri, Charlotte A. ;
Tyner, Stuart D. ;
Se, Youry ;
Lon, Chanthap ;
Spring, Michele ;
Char, Mengchuor ;
Sea, Darapiseth ;
Sriwichai, Sabaithip ;
Surasri, Sittidech ;
Wongarunkochakorn, Saowaluk ;
Pidtana, Kingkan ;
Walsh, Douglas S. ;
Fukuda, Mark M. ;
Manning, Jessica ;
Saunders, David L. ;
Bethell, Delia .
MALARIA JOURNAL, 2013, 12
12345678910