TFAM forces mtDNA to make a U-turn

被引：37
作者：
Hallberg, B. Martin [1 ]
Larsson, Nils-Goeran [2 ]
机构：
[1] Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden
[2] Max Planck Inst Biol Ageing, Cologne, Germany
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2011年 / 18卷 / 11期
关键词：
MITOCHONDRIAL TRANSCRIPTION FACTOR; RNA-POLYMERASE; CRYSTAL-STRUCTURE; COPY NUMBER; FACTOR-I; PROTEIN; NUCLEOIDS; RECOGNITION; ACTIVATOR; B1;
D O I：
10.1038/nsmb.2167
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mammalian mitochondrial transcription factor A (TFAM) is encoded in the nucleus and imported into mitochondria, where it functions as an activator of mtDNA transcription and packages mtDNA into DNA-protein aggregates called mitochondrial nucleoids. Two studies in this issue reveal that TFAM shapes mtDNA into a sharp U-turn, providing a molecular mechanism for its dual roles in the expression and maintenance of mtDNA.
引用
收藏
页码：1179 / 1181
页数：3
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