Gold nanoparticle conjugated poly(p-phenylene-β-cyclodextrin)-graft-poly(ethylene glycol) for theranostic applications

被引：25

作者：

Barlas, F. B. ^{[1
]}

Aydindogan, E. ^{[1
]}

Arslan, M. ^{[2
]}

Timur, S. ^{[1
,3
]}

Yagci, Y. ^{[2
,4
]}

机构：

[1] Ege Univ, Dept Biochem, Fac Sci, TR-35100 Izmir, Turkey

[2] Istanbul Tech Univ, Fac Sci & Letters, Dept Chem, TR-34469 Istanbul, Turkey

[3] Ege Univ, Cent Res Testing & Anal Lab Res & Applicat Ctr, TR-35100 Izmir, Turkey

[4] King Abdulaziz Univ, Dept Chem, Fac Sci, Jeddah, Saudi Arabia

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2019年 / 136卷 / 12期

关键词：

biomaterials; biomimetic; sensors and actuators; IN-VITRO; RADIATION-THERAPY; BETA-CYCLODEXTRIN; CANCER-THERAPY; DRUG; GLYCONANOPARTICLES; RADIOSENSITIVITY; ENHANCEMENT; PLATFORM; POLY(P-PHENYLENE)S;

D O I：

10.1002/app.47250

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Fluorescent conjugated polymers gained interest in the last decades for both imaging and targeting tumor cells for the purpose of diagnosis and treatment of cancer. In the light of this objective conjugated poly(p-phenylene) possessing beta-cyclodextrin (beta-CD) units in the main chain and poly(ethylene glycol) side chains is used as an imaging and therapeutic agent to target U87 and Vero cells. Additionally, imaging quality and therapy efficiency of the bare graft copolymer and its gold nanoparticle (AuNP) conjugated form were investigated and compared. It is observed that beta-CD is effective not only for the imaging of the tumor cells, but also as a radiotherapy agent. Conjugation of the polymer with the AuNPs provides significant improvement in the therapeutic efficiency. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47250.

引用

页数：6

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